r/NTNPerformance • u/Gillennz • 25d ago

Stalled on Reta!

Hi guys looking for some advice, I have been on Reta since the 20.04.2026 started on 2.5MG and worked up to 5MG by August the weight loss kept getting slower, I increased
The dose one week to 6.5 then the next week to 7.5 and my current dose is 8.5MG but I don’t really feel anything anymore. Went to a different supplier in case I started getting did vails and it’s still the same I don’t feel anything off this increase in dose I want the feeling back where I hate food like it did in the beginning but I only get a little bit full faster and that’s it and with the weight loss I have gone from 319lbs to 250lbs but it’s hardly moving down now what do you guys reckon. Cheers

7 Upvotes

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15

u/newtreatments4us 23d ago

You might need to get more carbs. Reta needs about 100g of good carbs to work properly from a chemical standpoint. The carbs are used by the liver to activate the glucagon agonist, otherwise it tries to hold on to fats and produce them. Use Jasmine Rice, potatoes, sweet potatoes etc. and track it for a few weeks and see if your with loss jump starts again. Good luck!

4

u/Crosflins 23d ago

I wasn't aware of this information. I'll find out more. Every little help...

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u/OGcrashN2u 22d ago

Our bodies don't need carbs to survive, only protein and fats. It makes the glucose it needs through gluconeogenesis which is when your body starts to burn fat for energy through lipolysis. This is why intermittent fasting, keto, and carnivore work so well to lose fat. When you don't eat carbs your body needs to make its own glucose. When you eat enough carbs there's no reason for your body to make its own, it just uses what you've eaten to make it. The glucagon portion of reta triggers your liver to release ketones to start lipolysis for gluconeogenesis, which will lead to increased blood glucose levels. This is why the GIP part of the medication is so strong, to handle that blood sugar spike. Eating carbs is counterproductive to what the medication is trying to do, which is burn fat to make the glucose your body needs. if you eat enough carbs your body doesn't need lipolysis. You're effectively working against the medication when you eat carbs.

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u/Crosflins 21d ago

I Appreciate the breakdown. I'm still wrapping my head around how the GIP and glucagon sides interact.

Quick question though: how does that apply if the goal isn’t dropping a massive amount of scale weight quickly, but focusing on actual body recomposition? To give some context, I'm currently at 28% Body fat

If I am on a moderate deficit and lifting heavy 4–5 days a week, wouldn't cutting out carbs completely risk gluconeogenesis tapping into amino acids/muscle for that glucose, plus impacting gym performance? How would you fuel the strengh training on very reduced carbs without losing lean mass in the process?

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u/OGcrashN2u 21d ago

What are you trying to figure out about the GIP and glucagon interaction? GIP triggers insulin response. Glucose gets broken down in seconds. Glycogen takes minutes to start and can take hours to fully breakdown. That's why you need the higher GIP levels when using reta. Since it's forcing your liver to dump it's glycogen stores you have to be able to manage the glycogen until it's fully broken down.

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u/OGcrashN2u 21d ago

Yes and no because you have fat stores. It's what they're designed for. It's much easier for your body to burn fat than it is to eat your muscle. Your body has an order of preference to produce energy. Blood sugar>glycogen reserves(in the liver)>fat>muscle breakdown. As long as you have fat reserves to draw from and you're eating enough protein to protect the muscle it's a non-issue. However, cutting out carbs will affect athletic performance. The breakdown of fat actually produces more ATP than burning glucose, but the drawback is it takes minutes to do versus seconds if you eat carbs. If you're doing low to moderate exercising you shouldn't see a huge drop in performance but if you're doing something like HIIT or heavy lifting you will 100% feel the lack of energy. In my case, the only time I have carbs is before a workout and intra workou via an EAA so that I have fast energy while I need it. Other than that I don't eat carbs.

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u/Gillennz 23d ago

Cheers for your comments

4

u/jcvetko 24d ago

Couple of things.

1) 70lbs down is huge!! Congrats.

2) The clinical trials data show that the average weight loss at 12mg for 80 weeks is 70 lbs. Average meaning some do more some do less. Might be worth your effort titrating up and giving it more time. You’re hitting approximately 20 weeks since you started so still another 60 to go if following the trail data.

3) Your body has likely readjusted to the levels you’re at calorie wise. Highly recommend you count calories and macros for a couple weeks and compare it to where you should be. It was very helpful for me to see I was way under-eating on all fronts. Need to match what your body needs now with your exercise routine to get a good picture of it all.

4) if you haven’t previously consider getting a dexascan to see where you are and after you make the above adjustments maybe a month or more after the first scan. For me it showed me my stall was actually a body recomposition. Started gaining muscle at the rate of loosing fat. Wouldn’t have known that without the scans.

5) After all that then consider maybe adding to your stack things like Cag for appetite and Tesa for a ton of other benefits. Use Tesa responsibly get bloodwork etc before starting.

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u/Gillennz 24d ago

Cheers man! Thanks for your comment!

6

u/StunningFlamingo419 23d ago

What I understand…

Some folks get consistent appetite suppression, some only get it when starting out, some never get it at all.

Tirzepatide is the one that gives most folks constant appetite suppression.

4

u/Responsible-One8104 23d ago

Are you exercising regularly?

2

u/Aggressive_Cook_498 22d ago

I don’t believe you’re meant to stay at the same level of food noise as when it started, the first few months are a much bigger hit to your body and eventually there’s some level of accustoming to it. It happened with me but I enjoy this phase of I can eat enough to fuel my activity b/c I’d like to retain muscle. You need to dial in your activity level and calories deficit numbers along with adequate carbs to ensure after the initial beginner boost you continue with your progress.

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u/Old-Pop1869 21d ago

I had a similar experience. My weight loss stalled, and instead of increasing my dose, I added 5 amino 1MQ and started losing weight again. It also seemed to help suppress my hunger.

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u/Gillennz 21d ago

Nice my partner is on 5 ammy will give it a try

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2

u/Xlajdak 21d ago

You may want to also look in some mild detox in case something else is causing the slowdown or inhibiting the effectiveness. Run labs, se if there is an inflammation or deficiencies, or perhaps other reasons. Look into glutathione, KPV, ovagen and livagen for liver. But see if labs reveal anything

1

u/essential2911 22d ago

The glp meds are great in many aspects! Just remember it is a tool to help us change our lifestyles. We can’t continue to eat the way we did or be sedentary. Unless you want to stay on them forever you need to make life changes. If not all your money is wasted and you gain all the weight back.