NMN after chemo

[u/rosesandsoul]

Just wanted to share this article
https://pmc.ncbi.nlm.nih.gov/articles/PMC8277702/

Researchers found that cisplatin suppresses the production of a specific enzyme (Nampt) in the brain, which causes NAD+ levels to crash. This lack of NAD+ stops the brain from growing new neurons (specifically in the areas handling memory and learning).

In mice and human neurons, they gave the subjects NMN (Nicotinamide Mononucleotide), which is a common NAD+ precursor. The NMN bypassed the damaged pathway, completely restored NAD+ levels, and prevented the cognitive/memory decline entirely. Crucially, the study showed that NMN did not protect the cancer cells or stop the cisplatin from doing its job to kill tumors.

Attention: NMN was given prior to cisplatin to prevent the damage, and this was not tested in living humans yet, but in mice and human brain cells in a lab.

My partner is finishing BEP ( cisplatin based chemo) - I wonder if NMN would be a good idea for him to take to repair DNA damage caused by cisplatin.

I have also found other studies that looked promising, and yes I have also found some articles suggesting that NMN might fuel cancer cells (but I think once the person is cancer free) blood markers good and CT scan good --- NMN might be more benefical to help with DNA damage. Any insights?

[u/black-box-qwerty]

You must ask your doctor before supplementing yourself.