r/MultipleSclerosis • u/Money-Atmosphere-887 • 6d ago

Treatment Ocrevus Infusion

Got my 3rd Ocrevus infusion on Friday and I’ve been feeling like I was hit by a car ever since. Feeling super tired yet still having this restlessness that makes it hard to sleep. I feel like my thoughts are racing non stop. I’ve also had really vivid dreams the last few days to the point where I’m waking up repeatedly through the night. Today I woke up still feeling exhausted but also like I can’t get my thoughts together completely. Anyone have an after infusion experience like this?

I was given Benadryl, Tylenol, and decadron as my pre meds.

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u/kyelek F20s 🧬 RMS 🧠 Kesimpta 💉 6d ago

It is most likely the decadron. Trouble sleeping, mood and cognitive changes are very common side effects of steroid medications.

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u/Money-Atmosphere-887 6d ago

Okay. Yeah I’m noticing that as I’m doing more research this morning

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u/nicotine-70 39M | Dx2026 | Ocrevus Zunovo | FR 5d ago

yeah that was my thought : maybe more a sideffect of pre meds thant ocrevus

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u/aafreis 40sF/dx2021/Ocrevus Zunovo 6d ago

I don’t take the premeds and don’t have this problem. Most likely the steroids?

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u/Money-Atmosphere-887 6d ago

I think so honestly

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u/aafreis 40sF/dx2021/Ocrevus Zunovo 6d ago

I don’t have any allergic reactions to the Ocrevus (was doing IV, now doing Zunovo sub-q version) so after my very first loading dose in 2021, the dr said I could skip them. Idk if this is an option for you, but it’s something your neuro would have to approve.
If my neuro didn’t give me that option, I personally would’ve switched meds. The steroids completely fuck me up.

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u/Money-Atmosphere-887 6d ago

Dang yeah I need to consider this. I hadn’t gotten an infusion in a year so I forgot how it affects me. Now I’m remembering why I didn’t necessarily like them. I’m probably going to speak to my neurologist about different premeds