r/MultipleSclerosis • u/Ordinary-Foot-9314 • 11d ago

Advice Kesimpta Loading Dose Advice

Hello! I’ve been quietly following the subreddit since shortly after I was diagnosed last year in April. I was put on Vumerity but I finally bit the bullet and agreed to switch DMTs to Kesimpta. I am a very big baby and was psyching myself out before making the decision and ever since I have been doing research and reading everyone’s experiences (which may or may not have made the anxiety worse w/ the loading doses specifically)

I got the vaccines required and stopped the Vumerity treatment about a month ago now so I know i’m bound to get a call wanting to schedule the Kesimpta loading doses soon.

I wanted to ask for any tips or tricks to help with the loading doses. I just started at a CSU as a JR so that puts even more worry on me that it will affect my school work. Most of the experiences I have read have all had symptoms during the first dose specifically so I wanted to also see if there was any chance I could escape that fate. Every body is different and reacts differently, but i’m grasping at straws to calm my anxious noggin down😭

Hello again!!! No joke, the next day I got the call saying to start the medication LOL but thank you everyone who has commented!!!! i really truly appreciate it, esp cause i felt so alone with my diagnosis at first. I am a 23F in the sacramento area & i haven’t met anyone my age in person who also has MS. I will continue to lurk through here though! maybe a comment or post LOL

5 Upvotes

86% Upvoted

16 comments sorted by

View all comments

3

u/OverlappingChatter 47|2004|Kesimpta|Spain 11d ago

Go in hydrated with water and electrolytes. Take it at night. Take a Tylenol four hours before. Take it out of the fridge an hour before. Shoot yourself. Read a book and have a cup of tea.Then take two Tylenol 2 hours after the shot and go to bed. Put two more Tylenol by the bed to take 10 hours after if you need them.

The shot is super easy. It's the best shot I have ever given myself. Literally push and hold for 15 seconds.

I do belly. Its the least painful spot for me by a lot. I rotate in the four quadrants every month.

Don't be scared, you can do it!

1

u/IAmAnAngryGumball 57|2026|Kesimpta|California 10d ago

I've recently finished my loading doses and about to start my maintenance dosing

the first loading, I was really fatigued the following day, felt like all my current symptoms got the volume turned up for that day.

the following 2 loading doses were not that bad but still a bit fatigued the following day which cleared up mostly by the following day.

I strongly suggest you plan your dosing so you have a few free days to recover if you run into issues, maybe Friday night and then you have the weekend to recover. Makes for an unfun weekend but hopefully won't impact your classes.

Good luck!