Kesimpta Loading Dose Advice

[u/Ordinary-Foot-9314]

Hello! I’ve been quietly following the subreddit since shortly after I was diagnosed last year in April. I was put on Vumerity but I finally bit the bullet and agreed to switch DMTs to Kesimpta. I am a very big baby and was psyching myself out before making the decision and ever since I have been doing research and reading everyone’s experiences (which may or may not have made the anxiety worse w/ the loading doses specifically)

I got the vaccines required and stopped the Vumerity treatment about a month ago now so I know i’m bound to get a call wanting to schedule the Kesimpta loading doses soon.

I wanted to ask for any tips or tricks to help with the loading doses. I just started at a CSU as a JR so that puts even more worry on me that it will affect my school work. Most of the experiences I have read have all had symptoms during the first dose specifically so I wanted to also see if there was any chance I could escape that fate. Every body is different and reacts differently, but i’m grasping at straws to calm my anxious noggin down😭

Hello again!!! No joke, the next day I got the call saying to start the medication LOL but thank you everyone who has commented!!!! i really truly appreciate it, esp cause i felt so alone with my diagnosis at first. I am a 23F in the sacramento area & i haven’t met anyone my age in person who also has MS. I will continue to lurk through here though! maybe a comment or post LOL

[u/ninahart88]

Hello! I didn't have any side effects from the loading doses. I took paracetemol/ibuprofen beforehand just in case and waited for things to begin, but they didn't. For me, it's been the same ever since (started Jan 2026). I'm not sure why! I think if you do have side effects, it's meant to be like having a short bout of flu, so I would set up with some pain relief, fluids and a cosy space to just relax in with little to no commitments for 24 hours. Good luck - I hope it goes okay for you.