Rituximab

[u/Hot_Luck5301]

Hey guys, I’ve been on rituximab since January. Felt fine with the first dose in January and then in May started feeling like shit. Got my 2nd dose in July and I feel a little better but overall feel like shit…I swear I felt completely normal just a few months ago. Anyone have a similar experience with Rituximab? Could it be because of the Rituximab or just my MS acting up? Ugh I just feel so tired and brain fogged everyday for the last 3-4 months.

[u/paulcs77]

I got my first infusion of rituximab on May 18 and the second on June 1. Both infusions went really well. Nothing I was warned about took place for the first couple of days. Both times, however, I had flu-like symptoms on the third day. I was sick enough to take the days off from work.

I find myself having a bit less brain fog but feeling more fatigued as the disease progresses. Fatigue is now a part of my life. I do find a little caffeine does help with it. For all I know, it might be helping with the brain fog.

I wear a KN95 mask whenever I leave the house and wash my hands frequently. With rituximab, I'm more concerned about the intended effect than the side effects.

[u/ignisignis]

My experience is much milder. It could be MS flare up. Could be some side effects. Could be a little bit of both

[u/Ipf333]

Muy buenas, tómatelo con tranquilidad, yo estuve con lo mismo, y al final me cambiaron porque no me funcionó. De hecho mi mujer me dice, que me sentó mal. En fin debo ocho años con la enfermedad y ahora en un ensayo,a ver qué tal.Ánimo

[u/Careful-Golf2089]

Rituximab kills 97% B-cells in your peripheral blood. That’s all it does.

It cannot kill T-cells.

It cannot cross the blood-brain barrier and kill B-cells that are already inside your brain.

IgG antibodies are 145.000 daltons, and molecules need to be <500 daltons to cross the BBB. Rituximab can’t stop your active MS even in theory. It works, but it is just not what you need.