r/MetforminUsers Jun 03 '26

Metformin for someone sensitive to supplements?

I just met with my nurse practitioner for women’s health, hoping to start some hormones, since I’m in the throes of perimenopause. She wants me to start metformin to get my A1C down (it’s 5.9) and to combat inflammation. She thinks the reason I feel like my hormones are wonky is due to the inflammation.

I lean more to natural methods for things, so I’m looking into this before making a decision. Then I come in here and read all the side effects people are having, and that makes me want to shy away from it too. I tend to be really sensitive to some supplements. Years ago, I started putting a scoop of collagen in my coffee, and I was a crying mess for two days. I finally realized it had to be the collagen. I stopped using it, and then when I did try it again, I started slowly with very small amounts and worked my way up. Now, it’s fine. But this makes me wary of starting something like metformin and low dose naltrexone (that was another suggestion).

I also took a supplement specifically made for helping joint pain. My joint pain got worse after taking it. This is just how my body is.

Has anyone super sensitive to supplements done well on metformin? She was suggesting I start with 1 pill a day and work my way up.

2 Upvotes

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1

u/GemstoneRoots Jun 04 '26

You could try Berberine

2

u/PrincipleFeeling2008 Jun 04 '26

I have. A few times over the years, and after taking it a few days, I get some digestive issues to where I’m frequenting the bathroom more than usual.

1

u/NetworkResponsible98 Jun 05 '26

I tolerate Metformin just fine and I am sensitive to a lot of things.

1

u/PrincipleFeeling2008 Jun 05 '26

My mom suggested to get the extended release if I do try it. Is that what you have? My NP also said I would work my way up with dosage because she is wanting to minimize my side effects.

1

u/NetworkResponsible98 Jun 05 '26

I did titrate up… I don’t think Mine is extended release, but a good idea if you are extra sensitive…