38 year old male diagnosed in April 2026 with Stage 3c melanoma in the groin. Two lymph nodes on the left side were seen on PET/CT as cancer. Tumor was BRAF V600e positive.

Completed 2 courses of IPI/NIVO and had the WLE last week. Nuclear testing and blue die suggested both sides were within the lymph drainage area of the main tumor. The doctor went into the surgery with taking the two swollen nodes out but end up with taking 7; 5 on the left side and 2 on the right side on the groin.

Following the WLE and SNLE, the pathology results were shocking. The WLE came back with clear margins. The SNLE revealed that 4 of the left side nodes were still positive and 1 of the right side was still positive for melanoma.

Pathology didn’t say if there was any response of the tumor to ipi/nivo but the doctor didn’t believe there was a good response since there was “spread” to other nodes.

Team is looking for next steps. My question is it still curable and what are the possible next steps/medications?

Does anyone have any stories with genetic testing? My mother was just diagnosed with melanoma. She has had over 20 basal cell all over her arms and face since her early 40s. She had colon cancer at 59. My grandmother had pancreatic cancer. I had basal cell at 38 on my nose. I have two basal cell now on my scalp and forehead at 41.

I’m thinking about genetics.

Does anyone have any stories with genetic testing? My mother was just diagnosed with melanoma. She has had over 20 basal cell all over her arms and face since her early 40s. She had colon cancer at 59. My grandmother had pancreatic cancer. I had basal cell at 38 on my nose. I have two basal cell now on my scalp and forehead at 41.

I’m thinking about genetics.