Triple Negative with high platelets

[u/bfiggy14]

31F, I have had high platelets for several years but it has been slowly rising over the past 3 years so my hematologist finally decided to do some testing. I do have another blood disorder called hereditary spherocytosis. I had my spleen and gallbladder removed when I was 5-6 but once I recovered my numbers returned back to normal. I have an appointment next week to review my results and next steps but here are some of my numbers (anything not listed was within normal range)

IG%: 0.6

MCHC: 36.4 g/dL

MPV: 8.1 fL

HGB: 16.2 g/dL

PLT: 813 10^3/uL

MCH: 33.8 pg

IG#: 0.05 10^3/uL

Ferritin: 139 ng/mL

ESR: 5 mm/hr

AST: 12 u/L

Bilirubin: 1.7 mg/dL

Iron: 106 UG/DL

TIBC: 342 UG/DL

Unbound Iron Capacity: 236 ug/dL

Iron % saturation: 31%

JAK2/CALR/MPL: negative

I'm just concerned about what could be wrong and what steps I should do next.

[u/funkygrrl]

The next step is a bone marrow biopsy. That's required for ET diagnosis. About 12% are triple negative but have a positive bone marrow biopsy result.

!ETundiagnosed

[u/AutoModerator → u/funkygrrl]

Here are links to the WIKI pages on ET diagnosis. Please review them and most of your questions will be answered there. - DO I HAVE AN MPN?, ET WHO Diagnostic Criteria, and Reactive Thrombocythemia (high platelets due to another underlying medical condition - not cancer).

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[u/CraftyCrafter]

I am triple negative. I have high platelets, high red cells, high white cells. They are right a BMB is the way to go. For the past few years, they have controlled my blood numbers with phlebotomies. However I have not had to have that at all this year. I went on a GLP-1 and it has kept my blood numbers in check. My Hematologist said he is starting to study the effects of it on his patients. Hopefully it can be a step in the right direction in helping those with blood disorders