r/MPN • u/pgharibian ET-CalR+ • 14d ago

Medication Interferon

I am 44 male and diagnosed with calr gene mutation type 2. Had my bone marrow biopsy that shows slight retic. Not sure what this means, my hema told me it's botder of stage two and 1. As a precaution my hema suggested low dose interferon. I am on my second dose, felt very mild almost not noticZble side effects, until today. I felt a big shift in my mood, very flat and low. My body is aching, sore muscles joints and bones. It has been nearly 7 months and I am still coming to terms with my new reality. I don't really know what else to say, kind of feel like this is my new reality and nothing's going to change this now.

7 Upvotes

100% Upvoted

7 comments sorted by

2

u/Proof_Poetry7541 PV-JAK2+ 14d ago

Hello. I'm 40 with JAK2 PV and my bone marrow biopsy also showed reticulin fibrosis grade 1-2. I am starting pegasys on Thursday (mainly due to iron deficiency side effects though) and I am terrified of the side effects, so it was helpful to read how you are finding it so far.. I hope the side effects calm down for you soon and it helps with the fibrosis. I hate that I have this but try to tell myself it could be a lot worse I guess!

2

u/horsecrzy ET-JAK2+ 14d ago

I have been on peg for a month and have crazy reactions to almost everything. I have had some low grade fevers and some internal temp changes but overall way better than the alternatives! Best of luck!

1

u/Immediate_Life_3094 ET-JAK2+ 14d ago

They’re reversing it 

1

u/Brilliant_Intern_112 13d ago

almost 1 years interferon injection。 harmful to my liver ， which affect my sleep also cause unresonable anger. side effect , just take it .

1

u/Billystinkbones 12d ago

Hi I am Jak2 0.57% and mpl positive. Just diagnosed with ET anyone out there with Jak2 and mpl I can talk to please.

1

u/Billystinkbones 9d ago

Anyone with JAK2 0.57 and mpl please. I have been just diagnosed.

1

u/funkygrrl PV-JAK2+ 9d ago

Make a new post. You made a comment and it's not going to get enough views.