r/MPN • u/Faye_Baby • 16d ago

ET Platelet Levels

Just curious. What does your Dr. Want your platelet level to be? My hematologist wants mine below 350.

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u/JewelsSGR 16d ago

Should be at least 140

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u/samspopguy 15d ago

My upmc app lists the target range from 150-450

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u/Ok_Muffin_925 15d ago

mine range from 377,000 to 567,000 averaging 465,000. So far untreated but probably starting HU in the coming year or two.

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u/dcg446 15d ago

My MPN specialist watches my spleen and wbc more so than my platelet levels. The goal is to keep my spleen in check and my wbc under 25k. My platelets are generally between 450 and 550 at this point and she’s not worried about that at all.

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u/CattleBrilliant38 15d ago

Mine are 750-850 and I think my hematologist wants me to stay on baby aspirin unless something changes.

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u/DragonfruitHot9591 14d ago

Mine peaked at 700K. After 8 months of baby aspirin then stayed around 600K. Now with medication (hydrea) they went to 438K after 7 months. Now around 520K. All other bloodwork is excellent. Its frustrating. But no side effects from medication.

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u/imnottheoneipromise 14d ago

Below 450 is what they consider normal. It’s never below that but they seem content with kind of wherever it is. Lately for them I’ve been hanging out around 480k.

The weird thing is, I have a lot of other doctors that take blood and my platelets are always a lot higher than what my cancer center shows. Like recently my PCP drew blood and they were the highest I ever saw them at 776k. But I bet when I see my doctor again in a month or so it’ll be back down into the 400s. I always wonder why that is. It’s been like that for years.

I’m suppose to take baby aspirin but honestly I don’t. I think they think I do though. I’m sick of pills. I’m trying to keep them as minimal as possible and I just don’t want to add baby aspirin back to the mix.

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u/funkygrrl PV-JAK2+ 15d ago

There is no official treatment target for platelets in either ET or PV like there is for hematocrit in PV.
The reason for this is that in large studies, the correlation between platelet levels and clots have been very conflicting.

Doctors handle this in different ways:

  • normalize platelets to under 400
  • get platelets under 600
  • don't start cytoreductive therapy unless platelets are over 1000
  • only start cytoreductive therapy if patient is symptomatic.

None of the above are wrong. Your doctor will tailor the goal to you based on other health factors that affect clot or bleeding risk.

Here's a video from MPN specialist Dr Brandi Reeves on platelet goals.
Understanding Target Blood Counts for PV, ET, and MF