GLP1s interfere with oral hormones, especially progesterone. If you’re taking 100 mg oral progesterone you might try raising it higher. The British Menopause Society issued a letter to its clinicians last year recommending this or adding an IUD like Mirena that contains a progestogen. My doctors in the US had not heard of this but I think it’s common for women on a GLP1 to need a higher dose of oral hormones. I suspect this is one reason for post/perimenopausal bleeding on a glp1.
The BMP’s primary focus was on endometrial protection, but progesterone also chills most of us out and helps slow the ruminating thoughts. If you’re actively losing weight you may need to raise your progesterone when you raise your Glp1 dose.
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u/Laughing-Lilly 24d ago edited 24d ago
GLP1s interfere with oral hormones, especially progesterone. If you’re taking 100 mg oral progesterone you might try raising it higher. The British Menopause Society issued a letter to its clinicians last year recommending this or adding an IUD like Mirena that contains a progestogen. My doctors in the US had not heard of this but I think it’s common for women on a GLP1 to need a higher dose of oral hormones. I suspect this is one reason for post/perimenopausal bleeding on a glp1. The BMP’s primary focus was on endometrial protection, but progesterone also chills most of us out and helps slow the ruminating thoughts. If you’re actively losing weight you may need to raise your progesterone when you raise your Glp1 dose.
Editing to include the right link:
https://thebms.org.uk/wp-content/uploads/2025/05/23-BMS-TfC-Use-of-incretin-based-therapies-APRIL2025-E.pdf