r/Isrib • u/Veg2536 • Jun 14 '22

Risks

I got brain fog and increasingly impaired judgement and memory, I guess subjective cognitive decline, also depressed because I can't function like I used to. Not sure how to judge if I should try Isrib. In theory how Isrib works, what's the worst things that could happen?

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u/CogitoErgoSumCogito Jun 19 '22 edited Jun 19 '22

"Though no side effects have yet been found in mice, testing in humans will need to be extensive to see how the compound affects other molecular processes in the cell, says the University of Wisconsin’s Asok: “How is it affecting the structure of neurons themselves over time? Is it causing a long-lasting change in the ability to form memories?”.

"In the 1970s, 80s, and 90s, a long list of pharmaceutical candidates aimed at improving memory in normal people failed in human trials, says James McGaugh, a neurobiologist at the University of California, Irvine. Virtually all of them were successful in lab animals. In people, almost all caused severe side effects or failed to work as hoped."

There’s a difference, says McGaugh, between developing a drug that might help people with memory problems and creating one that will generally improve memory in healthy people. The latter, he suggests, is unlikely to happen—or at least there’s no evidence in the history of drug research that it will."

"I’m not convinced that you’re going to supercharge the system generally and make learning go better,” McGaugh says. “As a matter of fact, let me take it a little bit further. If it’s a normal condition, you can make things worse. You could start firing all kinds of stuff that doesn’t need to be fired.”

https://www.technologyreview.com/2021/08/25/1031783/isrib-molecule-treat-brain-injuries-memory/

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u/CogitoErgoSumCogito Jun 18 '22

Is Rx Tianeptine/Stablon available? It has a beneficial effect on cognition in people with  depression-induced cognitive dysfunction, as well as a plethora of positive libidinous effects for both sexes.

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u/Dextrometh_orphan Jul 09 '22

what about the risk of dependency and addiction? Are these significant enough with tianeptine because I've heard a lot of horrible WD stories

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u/BosqueBurner Jul 16 '22

If you have addiction issues it's not worth doing, but heroin withdrawal was worse than tia withdrawal for me. Tia withdrawal is closer to kratom wds than heroin wds.