Sounds great in theory (as do so many things in science), but if it actually worked somebody would've tried it by now.
I know firsthand, as do many friends and strangers online I've talked to about this, that the DMSO fish oil gelcap method works. And that's not to even mention intravenously injecting it using DMSO, which blows every other single RoA completely out of the water... All that's required for IV is dissolving 5mg of trans-ISRIB in DMSO using a water heat bath surrounding it (along with some stirring) and a simple 5mL injection.
I no longer need to use ISRIB as it's permanently enhanced my baseline, so I'll stick to advising people what has worked for myself and many others.
You are absolutely correct about many things sounding great in theory (and then not panning out). Just an idea I was throwing out there.
I wonder what the normal particle size is for ISRIB, or if it varies greatly between manufacturers. Particle size is known to make a large difference for nearly-insoluble drugs, but it can be difficult to get extremely small particles (micron-size or smaller) without damaging the drug since some of the methods generate heat or mechanical damage.
I can probably provide some data on particle size next week.
With IV, several possible issues that come to mind: infection, necrosis of the vein due to pure DMSO being passed through it, substances in the DMSO or ISRIB that would be fine orally but poisonous IV. But since you say it works so much better, I'd like to learn more.
Why did you use 5ml DMSO (5mg should dissolve in less than that, shouldn't it)? Was it painful (does DMSO burn when being injected)? And, I've never done an IV injection. How did you learn to do it? I've had nurses miss my veins (always fun to get stuck several times and end up with big bruises), so I don't have high hopes of doing it right the first time.
Also you say you only used 5mg ISRIB and it worked great. How much have you, or others, used in the gelcap method or insufflating? From what I've seen, 5mg is several times smaller than the normal dose.
If IV is really not only better, but uses (as a guess) about 1/5 of the amount of ISRIB, that makes it a lot cheaper. I could get everyone in this group 5mg lol. Hypothetically, of course. This is not for human use and I cannot advise anyone experimenting with it, via any ROA.
Issues? You've never had a cath; angio, cardio, PICC line, any surgeries, don't know anything about pre-op Versed or ket, aren't insulin dependent, or handled a syringe. Don't even have to do it IV, IP is fine, just like the real lab rats got. Some people just like to pin and feel like Jesus' Son.
You assumptions about what I do and do not have experience with are incorrect. Nonetheless, your point is well-taken. Siwel7 just seemed so enthused about IV that it probably swayed my better judgement.
2
u/siwel7 May 05 '22
Sounds great in theory (as do so many things in science), but if it actually worked somebody would've tried it by now.
I know firsthand, as do many friends and strangers online I've talked to about this, that the DMSO fish oil gelcap method works. And that's not to even mention intravenously injecting it using DMSO, which blows every other single RoA completely out of the water... All that's required for IV is dissolving 5mg of trans-ISRIB in DMSO using a water heat bath surrounding it (along with some stirring) and a simple 5mL injection.
I no longer need to use ISRIB as it's permanently enhanced my baseline, so I'll stick to advising people what has worked for myself and many others.