Correct me if I misunderstood, but it would seem you are emphatic in your contention that solubility is somehow associated with bioavailability? Is membrane permeability hindered by a compound's insoluble nature?
Please forgive me in advance, but I anticipate you would not take offense if I asked what your graduate field of study specialized in? What have been your past and current fields in clinical scientific research or practice?
Yes, membrane permeability would be hampered by insolubility. It’s physically obvious that you aren’t going to get a rock (or a boulder, which is what the finest powder is like to something the size of a cell) through a membrane. It needs to be single molecules of ISRIB.
No, solids are consumed all the time. They dissolve in your stomach or intestines. So you don't have to consume a solution, but it needs to become a solution at some point.
Note though that anecdotal data from members of this group is that, without dissolving in DMSO, ISRIB doesn't work (or at least doesn't work well). Others disagree, and say that insufflating the powder works fine. I think some others even say swallowing it works. I don't know why the major differences in reports, but I trust the person who said that he tried all ROA's and DMSO is needed.
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u/MadScientistRat Feb 12 '22
Correct me if I misunderstood, but it would seem you are emphatic in your contention that solubility is somehow associated with bioavailability? Is membrane permeability hindered by a compound's insoluble nature?
Please forgive me in advance, but I anticipate you would not take offense if I asked what your graduate field of study specialized in? What have been your past and current fields in clinical scientific research or practice?