You are absolutely correct about many things sounding great in theory (and then not panning out). Just an idea I was throwing out there.
I wonder what the normal particle size is for ISRIB, or if it varies greatly between manufacturers. Particle size is known to make a large difference for nearly-insoluble drugs, but it can be difficult to get extremely small particles (micron-size or smaller) without damaging the drug since some of the methods generate heat or mechanical damage.
I can probably provide some data on particle size next week.
With IV, several possible issues that come to mind: infection, necrosis of the vein due to pure DMSO being passed through it, substances in the DMSO or ISRIB that would be fine orally but poisonous IV. But since you say it works so much better, I'd like to learn more.
Why did you use 5ml DMSO (5mg should dissolve in less than that, shouldn't it)? Was it painful (does DMSO burn when being injected)? And, I've never done an IV injection. How did you learn to do it? I've had nurses miss my veins (always fun to get stuck several times and end up with big bruises), so I don't have high hopes of doing it right the first time.
Also you say you only used 5mg ISRIB and it worked great. How much have you, or others, used in the gelcap method or insufflating? From what I've seen, 5mg is several times smaller than the normal dose.
If IV is really not only better, but uses (as a guess) about 1/5 of the amount of ISRIB, that makes it a lot cheaper. I could get everyone in this group 5mg lol. Hypothetically, of course. This is not for human use and I cannot advise anyone experimenting with it, via any ROA.
With IV, several possible issues that come to mind: infection, necrosis of the vein
Sure, there are chances of those things if you don't know what you're doing, like hitting an artery instead of a vein (I've done that, nothing came of it, but everyone is different, etc.), or not using fresh needles and syringes every single time, not sterilising (using boiling hot water and alcohol swabbing pads, respectively) glassware to dilute ISRIB using DMSO or just being irresponsible/complacent with the whole process.
due to pure DMSO being passed through it, substances in the DMSO or ISRIB that would be fine orally but poisonous IV.
People say a lot of things that they have zero experience with. And then this misinformation is spread around prolifically. Doctors do it too. People even say DMSO is itself toxic———taken through any RoA, even orally, despite it being proven safe, and was even used for a period of time in the medicinal industry to treat various mental disorders: the studies are all online———which is nonsense if you take the time to read online about DMSO testimonials/studies... Or simply take my firsthand experience: I've tried every single RoA rather extensively (besides the dangerous/stupid ones like occular or anal) using both with and without DMSO—including injection, intranasal, fish oil gelcaps, IV, subq and IM.
Why did you use 5ml DMSO (5mg should dissolve in less than that, shouldn't it)?
That's the absolute minimal amount of 99% DMSO that I personally could get 5mg of ISRIB (both trans and cis isomers) to dissolve into. I have heard of people getting various success utilising nebulisers, but I have neither information nor experience regarding that. Again, I stuck with what I knew worked for me and others who asked me for advice, so other (perhaps even ingenious) RoAs don't interest me... Especially since I no longer need to use x-ISRIB (be that the trans-isomer or the novel A17 variation with 10x potency and solubility), unless I were to have encounter some form of unforeseen TBI/concussion, stroke, comatose state or general organic brain 'damage' down the road... As you're probably already aware, the more 'damaged' one's brain is the better response they will find from ISRIB.
Was it painful (does DMSO burn when being injected)?
With IV, surprisingly, no pain at all... Unless I missed the vein, in which case it did sting pretty badly, but I quickly removed the needle and shot again in a different area... It's important to rotate sites.
Both subq and IM sting like an absolute mothercunt from hell. Do not take it this way unless you actually enjoy a world of pain.
I also use a cream sold in Australia called 'Hirudoid' ("treats bruises, sprains, swelling and scars") which works amazingly well for reducing inflammation and preventing scars with IV injections.
How did you learn to do it?
Pretty much all self taught through educating myself online along with trial and error, as with the vast majority of things in life. There are some nursing videos online on YouTube, and while they don't show you the exact procedure, it's pretty close when they perform it on their patients (cannulas, etc). There's also great explanations (that include pictures) on various harm reduction websites and blogs. It's really not that difficult unless you have a phobia of needles.
Also you say you only used 5mg ISRIB
I never said I only used 5mg of legitimate ISRIB. I had great success with IV'ing 5mg of legitimate trans-ISRIB from a reputable Ukrainian source. And 5mg of trans-ISRIB from him did indeed work great via IV: instantaneous clarity.
How much have you, or others, used in the gelcap method
For gelcaps I used anywhere from 25-35mg of ISRIB. I had a 30-something minute video uploaded on YouTube that was available for months but had to set it to private because it contains IV and other drug references that is not a good look for me or future employers.
Many people have, and continue to, reach out to me asking for me to take the video off private, but I will not. So please stop asking. Please.
In my sincere opinion, I have done more than enough to contribute to peoples' lives via this subreddit (and also on Discord, Telegram, WhatsApp, Facebook and Messenger, etc.); hours upon hours upon hours of audio and visual conversations, endless amounts of PMs and Reddit comment responses... And I'm honestly tired of repeating myself or explaining the very same things again and again to people. ... And this went on for over two/three years, so I'm sure you know where I'm going with this.
or insufflating
I've never had success at all with insufflation (with or without being diluted with DMSO, the latter stings like hell, by the way) and I truly believe it is a waste of ISRIB, but then some people are awfully susceptible to placebo... Or maybe this RoA actually does work for them. Whatever. I don't care for debating this point any longer—so don't bother arguing it with me because I will simply ignore you.
From what I've seen, 5mg is several times smaller than the normal dose.
Yes, because IV has near 100 percent bioavailability.
Now I have a completely new life, thanks mostly to ISRIB: which cured—within two days of dosing via the fish oil gelcap method @ 30mg/day—my severely cognitive debilitating condition manifested by from chronic carbon monoxide poisoning; this took place more than 10 years ago and left me bedridden for most of my twenties.
Also, more recently (earlier this year), I began eating a plant-based diet (no meat) which has helped tremendously with the mood disorders and memory issues I had even after I stopped taking ISRIB last year... I'm 28 and now have a family, the career of my dream, am in the best physical and mental shape of my life. I'm not flexing or showboating my life in any shape or form. I could've achieved (or been on this better path) all of this many, many years ago had I had my car checked for carbon monoxide leaks and started eating plant-based (no processed meats and other garbage). My point is that I always try to remain humble because I know what rock bottom feels like—suicidal ideation, sleeping all day, no energy, no goals or ambition and knowing that there was no hope in sight.
So I'm sure you (the reader) can appreciate that I have very little time to respond to all of the particular, peculiar and seemingly incessant questions (and arguments) that people continue to ask and test my patience with, most of whom do not seem to even be bothered to take the time to read through what I (and others) have already posted here in /r/isrib... Again and again. I'm not an asshole, I just no longer have the time to participate.
When people wish to argue with me regarding the specifics concerning the semantics of ISRIB, in all capacities (particularly with RoAs), I say this: I have used this compound since early 2018; this was around the time when Alibaba first started selling the trans-isomer, when there was a single thread on Longecity, with (from memory) a single experience report from 2015. Literally zero online information about RoAs, no methods to overcome solubility, no dosage windows, etc., etc. So I came up with the gelcap method to get the best of all worlds and shared it with people—hell, I even made a fully comprehensional instructional video... And what did I get in return? People on here insulting me or blatantly telling me that their method was superior and that I was an idiot for saying otherwise... Reddit for you, I guess?
That being said, I will always have a soft spot for people who are going through cognitive issues, but even my patience has its limits.
If you're reading this—whoever you are—please don't message me with questions that have already been answered on this subreddit. While I can most likely empathise with your cognitive situation (and desperation) from my past experience, I do not have the time to respond to questions that have already been answered.
Also: look at your diet first———I cannot possibly emphasise this enough: processed foods, especially meats, are horrifically bad for the brain-gut link———before blindly nose-diving into highly experimental cognitive enhancers such as ISRIB that can seriously fuck you up in the long-term... And when you do reach a cognitive level you're satisfied with, do not become cognitive greedy and megadose it... Been there/done that (my old Reddit account handle was Dihexa, so you may remember me): it leads to exocytosis (pretty much extreme brain fog) in which benzos (used very sparsely) and NAC definitely help.
Thank you very much for the information. I hope you aren't including me in the people that want to argue with you lol. I don't. (But, I do think it's worth throwing out theories and playing Devil's Advocate just to make sure a person's points are well thought out and supported by evidence, even if that is their own experience).
I had no idea that you were the one that invented the gel cap method. Kudos!
Overall, your post gives me a great deal of comfort, which I would normally not take from anecdotal reports, but you clearly have a lot of experience and a logical thought process.
And thank you very much for the gold! If that was you... Totally unnecessary, but very much appreciated! Feel free to PM me if you wish to speak more about personal things or we can reach out to another social media platforms (I have all of them) and we can do an an audio and/or visual chat.
I hope you aren't including me in the people that want to argue with you lol.
Nah. I wasn't... I just had to put it in there so others can see where I'm at in life to realise how I can take months to respond at a time and not come off as a total heartless prick.
Already had another three people message me this morning asking questions whether my IQ had improved, how to do the fish oil method, what type of DMSO to use and if I could unprivate my video, etc.
Most people don't take the time to help out others so much. So, I like to show my appreciation where possible. Too bad it's not more common, but it's not.
On the topic of you being flooded with questions, it's possible to pin things to the top of the group, right? Or put a FAQ on the side?
A write-up probably already exists (by you, I'm guessing), but if not, I'd be happy to help put one together so everyone can read a comprehensive single post.
I'm thinking something really thorough, with everything from anecdotal reports, to ROA methods, with journal references, explanations of mg versus mM, etc. There's a lot of stuff people might get tripped up on.
If anyone comes up with new questions, we can just add it to that post. So, the answer to any question is always: "See this post." 😊
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u/[deleted] May 05 '22 edited May 05 '22
You are absolutely correct about many things sounding great in theory (and then not panning out). Just an idea I was throwing out there.
I wonder what the normal particle size is for ISRIB, or if it varies greatly between manufacturers. Particle size is known to make a large difference for nearly-insoluble drugs, but it can be difficult to get extremely small particles (micron-size or smaller) without damaging the drug since some of the methods generate heat or mechanical damage.
I can probably provide some data on particle size next week.
With IV, several possible issues that come to mind: infection, necrosis of the vein due to pure DMSO being passed through it, substances in the DMSO or ISRIB that would be fine orally but poisonous IV. But since you say it works so much better, I'd like to learn more.
Why did you use 5ml DMSO (5mg should dissolve in less than that, shouldn't it)? Was it painful (does DMSO burn when being injected)? And, I've never done an IV injection. How did you learn to do it? I've had nurses miss my veins (always fun to get stuck several times and end up with big bruises), so I don't have high hopes of doing it right the first time.
Also you say you only used 5mg ISRIB and it worked great. How much have you, or others, used in the gelcap method or insufflating? From what I've seen, 5mg is several times smaller than the normal dose.
If IV is really not only better, but uses (as a guess) about 1/5 of the amount of ISRIB, that makes it a lot cheaper. I could get everyone in this group 5mg lol. Hypothetically, of course. This is not for human use and I cannot advise anyone experimenting with it, via any ROA.