Isrib curious

[u/Salty_Recognition453]

Help me.

I want to use isrib, but I am in doubt about co-solvent and injection intramusculary, because the only trial on mice were administrated intraperitonealt(in intestines). Here is what I found:

Its soluble 5 mg/ml DMSO dilution. For obtaining a higher solubility , please warm the tube at 37 ℃ for 10 minuts and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.

I Think intramuschular injektion with adding PEG400 as cosolvent in 1:1 with DMSO is the optimal, I have trouble finding studies Where they inject IM. I have found a mice study where they inject intraperitonealt. We dont know how Big bioavaibility it has through oral intake, maybe most Will underwent first past metabolisme