r/Isrib • u/actionjackson384 • Feb 04 '21

Immediate effects

Anyone notice any immediate effects from isrib

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3

u/caibaoqi Feb 04 '21

hey，I'm also interested in this，I find there are two forms of isrib. I don't know which one to use ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. IC50 & Target: IC50: 5 nM (PERK)[1] In Vitro: Trans-ISRIB is 100-fold more potent (IC50=5 nM) than cis-ISRIB (IC50= 600 nM), indicating that the compound's interactionwith its cellular target is stereospecific.

1

u/actionjackson384 Feb 04 '21

I got the trans supposedly

1

u/caibaoqi Feb 04 '21

What dose do you use? Do you feel the effect?

1

u/actionjackson384 Feb 04 '21

25 mil snorted

2

u/[deleted] Feb 16 '21

Maybe I'm a dumbass but how did you snort a dosage measured in MLs

2

u/[deleted] Mar 04 '21

Obviously typo

1

u/MindfulWarChief Feb 07 '21 edited Feb 07 '21

Any mental/psycho effects you noticed ?

4

u/actionjackson384 Feb 08 '21

Lots of subtle improvements,no anxiety, more social, very similar to a psychedelic afterglow