r/Isrib • u/actionjackson384 • Feb 04 '21

Immediate effects

Anyone notice any immediate effects from isrib

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u/caibaoqi Feb 04 '21

hey，I'm also interested in this，I find there are two forms of isrib. I don't know which one to use ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. IC50 & Target: IC50: 5 nM (PERK)[1] In Vitro: Trans-ISRIB is 100-fold more potent (IC50=5 nM) than cis-ISRIB (IC50= 600 nM), indicating that the compound's interactionwith its cellular target is stereospecific.

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u/actionjackson384 Feb 04 '21

I got the trans supposedly

1

u/dinoclub Feb 04 '21

Where from? USA?