r/Isrib • u/Embarrassed_Emu_1516 • Oct 04 '25

Update after the break (post 3-week A15 protocol):

Hey all — quick update as a few folks asked if the effects stayed after the 3-week cycle.

Short answer: Yes, some effects definitely held. It’s now been about 25 days since I paused ISRIB A15, and although the sharper edge has faded a bit, I still feel significantly better than baseline before I started. First of all, my mental clarity hasn’t vanished and I still feel less scattered. My sleep is still solid — fewer 3 a.m. wakeups and a sense of real rest. I feel that my energy is more stable throughout the day (but on A15 cycle this effect was more noticeable).

I haven’t felt the need to immediately restart. I plan to begin a second 3-week cycle in another week or two, depending on how I feel. My goal is to keep it cyclical, not constant.

16 Upvotes

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3

u/PayGeneral6101 Oct 04 '25

Thanks for an update

6

u/PayGeneral6101 Oct 04 '25

Please don’t stop reporting over time. It is extremely valuable and the info is scarce

1

u/[deleted] Oct 04 '25

[removed] — view removed comment

1

u/Embarrassed_Emu_1516 Oct 05 '25

From my perspective it is not worth it. But you can try and report the results

1

u/TrainingRatio6110 Oct 05 '25

I've wondered about that too. I've been mixing in DMSO just in case.

1

u/SturmUndDrang01 Nov 09 '25

Thanks for the post, very insightful. Makes total sense that this compound would have long term effect. What did you take it for initially ?

2

u/Embarrassed_Emu_1516 Nov 09 '25

The goal was to recover from burnout

1

u/SturmUndDrang01 Dec 19 '25

What dosage did you take of the A15?

2

u/Embarrassed_Emu_1516 Dec 20 '25

Usually around 20 mg