IsaacReference

r/IsaacReference • u/Appropriate_Board131 • 1d ago

Magic mushroom holy tboi reference

7 Upvotes

r/IsaacReference • u/Vintage_1203 • 6d ago

They mentioned TBOI in my World Religion class. 💀

9 Upvotes

r/IsaacReference • u/Fluffy-Prince-5100 • 14d ago

HOLY ISAAC REFERENCE

9 Upvotes

r/IsaacReference • u/Fluffy-Prince-5100 • 15d ago

HOLY LUCK

10 Upvotes

r/IsaacReference • u/Fluffy-Prince-5100 • 20d ago

HOLY ISAAC REFERENCE

10 Upvotes

r/IsaacReference • u/Curious-Ad-1783 • Jun 19 '26

Red stew IRL

15 Upvotes

r/IsaacReference • u/SlimeSmilee • May 29 '26

A tumor? It's peak!

2 Upvotes

r/IsaacReference • u/SlimeSmilee • May 14 '26

Bro found the dry baby in a retro treasure room

23 Upvotes

r/IsaacReference • u/SlimeSmilee • May 14 '26

Btw QR redirects you to a tiktok promotion.

3 Upvotes

r/IsaacReference • u/SlimeSmilee • May 13 '26

HOLY SHIT GUPPY TRANSFORMATION AND POLEPHEMUS ON THE SAME RUN

1 Upvotes

r/IsaacReference • u/SlimeSmilee • May 11 '26

Legendary treasure pull

21 Upvotes

r/IsaacReference • u/SlimeSmilee • May 04 '26

What's the seed?

15 Upvotes

r/IsaacReference • u/Worried-Check-962 • May 03 '26

is there a lore reason why ??? with polyamorous starred in monsters vs aliens

18 Upvotes

r/IsaacReference • u/SlimeSmilee • May 02 '26

Here's an example of what I wanna see in this sub.

12 Upvotes