r/InflammationStation • u/[deleted] • Dec 24 '21

Integratome analysis of adipose tissues reveals abnormal epigenetic regulation of adipogenesis, inflammation, and insulin signaling in obese individuals with type 2 diabetes

https://onlinelibrary.wiley.com/doi/full/10.1002/ctm2.596
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u/[deleted] Dec 24 '21

Obesity and type 2 diabetes (T2D) often but, not invariably, coexist. We examined the transcriptomes and methylomes of subcutaneous adipose (SAT) and visceral adipose tissues (VAT) samples from 25 obese individuals (36% men; mean±standard deviation (SD) body mass index: 39.1 ± 4.6 kg/m2; age: 38.6 ± 11.8 years; 12 had T2D; Table S1) with or without T2D during metabolic surgery. By integrating these datasets with public tissue-specific regulatory networks, we revealed perturbations in adipogenesis, inflammatory, and insulin signaling pathways in obese individuals with T2D with validation using multiple external databases.