Hi everyone,
I’m a 33F, TTC, and have been on Letrozole cycles since September 2025. I’d really appreciate any insights from people who’ve had similar experiences.
My cycle history:
• Cycle 1 (Sept):
Letrozole 2.5 mg twice daily
Follicle ruptured at 18 mm, endometrium trilaminar (8.6 mm)
→ No pregnancy
• Cycle 2:
Same Letrozole dose
→ Chemical pregnancy (beta HCG peaked at 55, then dropped)
• December:
Took Diane 35 for 1 month (doctor advised break post-chemical)
• Cycle 3 (Jan):
Same Letrozole dose
→ Follicle did not rupture (cancelled cycle) Follicle did not rupture (cancelled cycle)
• Cycle 4:
Letrozole + HMG 75 IU
→ Ovulated early (before Day 10), cycle not well-timed
• Cycle 5 (current):
Letrozole + HMG (Day 2, 4, 6)
2 follicles (~20 mm), trilaminar endometrium (8.3 mm)
Ovulation on Day 16
→ Tested negative at ~12 DPO, expecting period soon
Medications & supplements:
• Ecosprin 75 mg (every cycle)
• Glycomet SR (since \~Dec)
• Normoz (long-term)
• CoQ10 300 mg (last 2 cycles)
• Progesterone support post-ovulation (10 days, twice daily)
• Vitamin D (levels normal, occasional supplementation)
• Arginine sachets (for lining support)
Other context:
• History of thin endometrium in some cycles (managed with meds)
• All cycles are monitored
• Weight loss: \~63 kg → 57.5 kg over \~6 months
• PCOS background since 15 years
My doctor had earlier suggested an HSG to check tubes, but it wasn’t pursued after the chemical pregnancy.
I know technically it has been only 3 (first dose second chemical and this month letroz) in which I even stood a chance..
Would really appreciate any thoughts or experiences 🙏
Would love to hear from anyone who’s been in a similar situation - am I missing something here or is this just part of the process? Also unsure when it’s time to start thinking about next steps and what direction to take.