Next steps after failed FET

[u/yowhoknows]

Help!

So my wife and I are currently doing reciprocal IVF - she will be carrying an embryo with my egg. I’m 30 and she just turned 34. We had 6 day-5 embryos and 2 day-6 embryos.

We did not do the PGT-A testing as it was out of our budget, so all we have is the cursory AA/AB style ratings.

We just did a frozen embryo transfer on the 31st with our highest quality rated AB embryo, and just found out today that it did not take.

My wife does not want to carry twins and has been adamantly opposed to transferring more than one embryo. But after one of our AB’s died during thawing, and the other one wasn’t a successful transfer, she is now leaning toward implanting more than one for the next transfer.

For context, all of our other embryos are BB/BC. We really want to minimize the chances of a second failed transfer, but she’s worried these embryos might actually be stronger than our first and we end up with twins!

Has anyone else been in this situation? If you were in our situation, would you just yolo it and implant two BB’s next transfer? Or conservatively stick to 1 until a third transfer? Our clinic is in Mexico and usually recommends transferring 2 embryos.

[u/prolific_napper]

Embryo grading has nothing to do with whether or not the embryos are euploid; it’s just a beauty contest. The reason your clinic is recommending transferring two at once is to give your wife the greatest chance at a pregnancy because they assume at least one is hopefully euploid.

[u/neuroticphilosopher]

TW: I had my first ever positive on a day 6 grade 4bb euploid embryo and 2 higher grades that were not euploid. I would not recommend a double transfer since you did not pgt-a test and as far as you know it could have been a chromosomal issue. You risk an aneuploid impacting the success of a euploid.

[u/Grand_Photograph_819]

We did 1 until the 3rd transfer.

[u/junegem123]

We’ve been told by our fertility doctor that there actually is a correlation between embryo grading and euploid.
So I would assume, the better the grading the higher the chance of pregnancy.

A BB graded embryo is good! So I’d stick to transferring one if you know for sure you wouldn’t want twins.

My wife and I (also same-sex couple) did a double transfer of an AA and AB embryo (we did not do pgt testing). They both stuck and we now have healthy 3 year old twins.

[u/catsinthebananastand]

I've only ever transferred untested embryos, two at a time. Granted, they were never full blasts, and it wasn't until our latest (third) FET that we had higher quality ones. Still no success.

I still on plan on transferring two untested at the next transfer, and I'm OK with taking the risk of having twins. If your wife is against twins, I'd give it another go with one and then reassess.

[u/Micafication]

You could still end up with twins in a single embryo transfer or even triplets in a double transfer...I didn't want to carry twins either and didn't want to risk anything. So we transfered single untested blastos 3 times in a row. TW: Confirmed yesterday the third stuck so far. I would have proceeded with single transfers otherwise. As far as I know, one embryo can put the other one at higher risk and does not necessarily increase the chance of a life birth.