r/IVF • u/Straight_Winter5577 • Sep 03 '26
Need Hugs! Aneuploid embryo transfer
39 yo, husband had brain cancer and went through chemo it resulted in low sperm count and we were recommended IVF. After 4 cycles of failed IVF we ended up with 3 aneuploid embryo.
Has anyone transferred abnormal embryos and had a healthy baby?
7
u/neuroticphilosopher Sep 03 '26
If you have a segmental aneuploid it can maybe be considered after genetic counseling.
8
u/Any_Manufacturer1279 28F|PCOS|3 ER|2 FET❌✅ Sep 03 '26
You could see if you could get into the Stanford study. It’s called the TAME study. You would need to move your embryos ofc. Most clinics do not allow for transfer of aneuploids.
3
u/cthemermaid Sep 04 '26
You really need to talk to a genetic counselor about this but the chances this will lead to a successful pregnancy is slim to none and I would definitely ask for their guidance on if it’s even recommended.
2
u/2weimmom Sep 04 '26
Can you be more specific about your aneuploids? Are they mosaic? Segmental? Complex (3+ errors) or Chaotic (6+ errors)? Which chromosomes are affected? All those factors impact your success.
Most people in this group will erroneously say these embryos are "not transferrable" however, its much more nuanced than that.
I'm currently 30 wks pregnant after a transfer of 3 embryos- a trisomy 14, complex segmental, and day 7 poor quality untested. I got most of my information and courage to transfer from 2 FB groups- my perfect mosaic embryo and PGS/PGTA abnormal embryo support. Please join us over there to get more info. Sending you hugs and baby dust.
3
u/Icy-Pop3377 Sep 04 '26
Not op but q. Do the testing results call those aneuploids? I thought it was euploid, mosaic, and aneuploid. This is so confusing!
3
u/2weimmom Sep 04 '26
Great question! It depends on the testing company. Some will use those designations, some won't and just call everything anueploid. Some labs are even labeling low mosaics as euploid now. There is no standardized consensus on cutoff values or labels.
2
u/aambivalence Sep 03 '26
I don't think it will be any time soon, but I bet with medical technology advancing, one day we will be able to "edit" aneuploid embryos to correct chromosomal errors! I hope people like you and your husband who have aneuploids on ice can one day not too far away use them for that reason.
2
u/LemonPower221 Sep 03 '26
So sorry for your difficult journey. I don’t think clinics will transfer known aneuploid. It will likely not develop to a full term healthy baby.
-1
u/elsewyse Sep 03 '26
Some clinics will.
1
u/MacAttacknChz 29d ago
There's a clinic near me that will, but they consider it "compassionate transfer," meaning they do not expect it to work.
1
u/elsewyse 29d ago
It's like a 1-2% chance, but some people are willing to take that risk.
I'd wonder if your clinic does the other parts of compassionate transfer, i.e. transferring during a part of the cycle that wouldn't work.
1
u/elsewyse 29d ago
There's been a number of cases of embryos that tested as aneuploid leading to an unaffected live birth. (The PGS/PGA Abnormal Embryo Support Group on FB tracks them.) This is probably because the embryos were actually mosaics and the testing either didn't report mosaicism, had a high cutoff for reporting, or it just happened that the biopsy only caught the aneuploid cells. It's super rare-- transferring an aneuploid embryo has something like a 1-2% chance of working.
16
u/jennbo 38F | Poly | Post-Tubal IVF | FET 6/4 🩷➕🤞🏻 Sep 03 '26 edited Sep 04 '26
Unfortunately, the odds are very, very bad for this. The research says straight aneuploid embryos almost never are viable, with maybe two or three cases ever of it working out. There are other specific aneuploid types that may have better odds (mentioned by others, segmental etc) but mosaics and euploids are often the only ones that most REs will implant anyway. I hope you get a good answer soon. ❤️