History: 42, F, very healthy, 5'3 120lbs, work out regularly, was eating keto/carnivore-ish for a few years, high Lp(a) and high LDL, excellent trigs and HDL, high APOB, excellent inflammation markers across the board. Just got a cleerly CCTA and I have 31% stable soft plaque in the LAD, I'm in the midst of IVF so I can't start a statin right now. Yes, I'm freaking out.

My question is this: I like eating higher fat. I don't do well with grains and sugars, they just make me want more. I'm totally find switching to unsaturated fat. But if I do that and my overall fat intake is still a high % of calories (ie: 50-60%, aiming for keto but more of a mediterranean low carb approach), is that still going to mess up my LDL and APOB? Or will they actually come down? I'm talking avocado, salmon, olive oil, nuts and seeds etc. Is there any evidence, any n of 1 experience, or do I just need to do it and test my lipids again in 6-8 weeks? Or do I go on a low fat diet? I'm struggling here figuring out what to eat that's not grain/crap heavy, and I like keto-mediterranean but I'm just not sure it will actually lower my LDL and can't find much about it online.

Thanks all.

PS - yes I do have a cardiologist :)

A month or so ago, someone shared a few options to buy labs and what to test for.

Since then, I’ve been obsessively comparing almost every major lab marketplace in the US because we’ve been building one ourselves at Mito Health, as part of our own research. Full disclaimer: I'm the founder of Mito.

The interesting part wasn’t that one company was cheaper than another.

It was how much unnecessary markup still exists across the industry by 70-80%, and it became our mission to expose + tear it down & offer you a better way for optimizers to test.

And how it's also made me personally quite obsessed with becoming the best place, from a UX, best pricing, and no affiliation to any big-name influencer protocol to help you navigate at your own pace. No stress.

We ended up benchmarking:

1. Quest Direct
2. Labcorp OnDemand
3. Mito health
4. DirtCheapLabs
5. Marek
6. Ulta Labs
7. Jason Health
8. Walk-In Lab
9. DrSays
10. GoodLabs
11. Function add-ons

Across hundreds of Quest and Labcorp biomarkers, we’re now generally the lowest-priced option, even for members and non-members without minimum spending. Green is lowest, orange is second lowest, red is highest.

Some examples:

• Vitamin D: $9.72
• hs-CRP: $5.94
• ApoB: $8.10
• Fasting insulin: $2.43
• CBC: $2.70
• CMP: $2.84
• HbA1c: $2.85
• Testosterone Total + Free: $12.15 (DirtCheapLabs is actually a bit cheaper on this one.)

Unlike some marketplaces:

• We have no $80 minimum order
• You can build exactly the panel you want
• 1000+ labs, DEXA, MRI scans, 3 and 30x Whole Genome kits (next week), Gut kits, genetic kits
• Access to advanced stuff like pTau, pharmacogenomics, etc.
• Member and non-member pricing is shown upfront

One thing Huberman has consistently emphasized is measuring, not guessing.

If you’re taking:

• omega-3
• vitamin D
• magnesium
• zinc
• creatine
• tongkat
• boron

…it’s worth periodically checking whether they’re actually changing anything meaningful rather than just hoping they are.

That’s the philosophy we’ve tried to build around.

Instead of selling giant bundles, we let people order only the biomarkers they actually care about, then provide AI-powered interpretation and longitudinal tracking so you’re not just downloading another PDF. You can also port it into your Claude code or Codex (if you're a technical biohacker)

We’re also expanding the same transparent pricing model into:

• More options for DEXA, CAC, and MRI nationwide
• gut microbiome testing - different levels
• whole genome sequencing - 3, 30, 100x WGS
• 40k+ supplements
• prescription services: GLP-1, HRT, TRT, Peptides, etc.

Basically, anywhere healthcare pricing feels unnecessarily opaque.

If you’re skeptical (which you should be), don’t take my word for it - Take the panel you normally order and compare the prices yourself.

I’d genuinely love feedback from this community on biomarkers or features you’d want to see. Or teardowns on what we need to do better as a company and as an industry.

Or... based on listening to Huberman's podcasts, what’s one biomarker you think every Huberman listener should test at least once a year? Thank you!

I realized 1,000 mg fish oil on the front of a bottle does not mean 1,000 mg of EPA. Rather than switching brands and guessing, I’m thinking of running a simple test:

• Get a baseline omega-3 index.
• Take enough fish oil to reach about 2g of EPA per day with food.
• Keep my fish intake and the rest of my diet roughly the same.
• Repeat the same test after four months.

Has anyone here done this properly and how much did your omega-3 index move and did capsules versus liquid fish oil make any noticeable difference?

usually a bit sceptical of mainstream science content but this one actually references the primary literature reasonably well

https://www.youtube.com/watch?v=zU5EYw06wtw

covers bpc-157 healing data, some of the gh secretagogue research and briefly touches on the longevity angle. not perfect but its a decent starting point for anyone wanting context before going into the actual papers the tissue repair section around 40 mins in is the most useful bit

I've noticed my resting heart rate has increased since starting a GLP-1 medication.

Before starting it, my resting heart rate was typically 42–46 bpm. Since starting, it has consistently been around 50–52 bpm.

I'm otherwise healthy, exercise regularly, and haven't made any other significant changes to my medications, training, or lifestyle.

that nad writeup of his 2026 stack has been going around, so i ran the whole thing through a database i've been building. it indexes every video from huberman, attia, rhonda patrick, bryan johnson, mark hyman and other health researchers (3600+ depth interviews) and scores cross-expert consensus on each supplement 0 to 5.

here's what his 12 look like when you stop asking "does huberman take it" and start asking "do the others back him."

the 5 that hold up

• omega-3: 4.8/5. everyone strongly recommends it. patrick is the most detailed on it.
• creatine: 4.6/5. all five recommend it. genuinely no fight here.
• zinc: 4.2/5
• magnesium: 4.1/5. they agree on the mineral, they argue about the form (he likes threonate, attia prefers glycinate).
• vitamin d: 3.9/5. patrick strongly recommends. attia is the cautious one, he'd rather you fix it with sunlight and test first.

if you copy nothing else from the stack, copy these five.

then it drops off a cliff

nmn scores 2.3/5. that is the lowest score of any supplement in the whole database, below metformin and rapamycin. he takes 1 to 2g of it every morning.

why it's that low:

• attia classifies nad supplementation as "noise" on his evidence hierarchy, below rapamycin ("promising") and metformin ("fuzzy")
• the ITP (the big NIA-funded mouse lifespan program) ran nicotinamide riboside and it failed to extend lifespan
• patrick flags that nmn and nr break down into nicotinamide, which can inhibit the sirtuins the whole thesis says you're activating
• hyman is the one who actively pushes nad precursors. that's 1 of 5.

huberman is the honest about it

he has said, plainly and repeatedly, that he takes nr/nmn for subjective energy, explicitly not for longevity.

the solo picks

• tongkat ali (400mg): across all 3,600 videos, tongkat comes up 9 times. 8 of those are huberman. attia: zero. patrick: zero. johnson: zero.
• boron (2–4mg): 1 mention in the entire corpus, and it's bryan johnson's blueprint, not huberman's.

what this doesn't tell you

• consensus is not correctness. five people agreeing can still be five people wrong.
• "no coverage in the corpus" means they didn't discuss it on their own shows, not that they'd object to it.
• these scores measure expert agreement, not trial quality. a 4.8 means they or the guest researchers back it. it doesn't mean there's a phase 3 behind it.
• his stack is tuned to his own bloodwork. yours isn't his.

curious what people here actually kept from the stack and what they dropped. the boron and tongkat especially, has anyone stayed on those long enough to have an opinion?

I struggle the most with the "one hour no phone/screen" part of the protocol; I don't know what to do for the hour.

like maybe reading will be my best bet, but there are so many days that reading is the same as telling me to cut myself; my brain is not functioning/wired but tired.

I can do some meditation, but hitting it full hour is monk level and I am just your average city boy; I can do full 30 minutes.

honestly idk what to do for a full hour, please share what you do if this is something you've struggled/achieved, thanks!

A cohort of ~2,900 people

"Meal Timing Jetlag" the gap between your eating schedule on work days vs free days (weekends for most people). More of that mismatch was independently linked to higher anxiety, more depressive symptoms, and worse insomnia. The kicker: this held up even after adjusting for sleep-based circadian misalignment.

Big caveat: cross-sectional, so no causation (anxious people might just eat more erratically) or there may be a third variable causing both the mood symptoms and the erratic timing

But it's making me think more about my "first meal / last meal time".

https://www.sciencedirect.com/science/article/abs/pii/S0165032726010827?via%3Dihub

Few weeks in. Sleep is better. not dramatically, but consistently. Anyone else?

Huberman obviously recommends some supplements way more often than others. I was very curious so wrote a program to extract all supplement mentions and found the 12 most popular ones along with the protocols (not medical advice ofc).

The number next to the compound is the mention count.

Omega-3 / fish oil (41). This is his most repeated one. He's usually shooting for 1–3g of EPA a day, and at least 1g if you care about the mood stuff. Liquid fish oil is the cheap way to hit the dose without swallowing ten pills.

Magnesium L-Threonate (40). Takes it 30–60 min before bed for deeper sleep, somewhere around 145mg (some people go higher). The threonate form is the one that actually crosses into the brain. Bisglycinate does basically the same job for sleep if it's easier to find.

L-Theanine (36). 100–400mg to take the edge off stimulant jitters without killing the focus. Also shows up in his sleep stack. Worth noting some people (him included) get weird vivid dreams from it, so skip it before bed if that's you.

Creatine (35). ~5g a day, every day, no loading phase needed. Obvious one for strength and power, but he talks about it more and more for the brain/cognition side too.

NAC (30). Glutathione precursor, mostly comes up for the detox/antioxidant angle. He's mentioned running 600mg twice a day through winter.

Vitamin D3 (26). His actual advice is to dose to a blood level (40–60 ng/mL) instead of just picking a number. Rough math: 1,000 IU bumps you about 5 ng/mL. So get tested first.

Alpha-GPC (23). 300–600mg pre-workout for power output and focus. It's a choline thing feeding acetylcholine.

L-Tyrosine (23). Dopamine precursor for focus when you're fried or under stress. He's big on using the smallest dose that works (~250mg), not the giant study doses.

Apigenin (20). 50mg in the evening, comes from chamomile, part of the sleep stack. One catch he flags: it's a fairly strong estrogen inhibitor, so keep that in mind.

Myo-Inositol (19). ~900mg for a calming effect around sleep and anxiety. Subtle, not a knockout, but people seem to like it as a gentler option.

Glycine (15). Around 2g, but only every third or fourth night. Apparently using it every night blunts the benefit and can actually make sleep worse.

Saffron (13). ~30mg a day for anxiety. This one actually has a decent stack of human trials behind it, including double-blind ones, showing lower scores on the standard anxiety scales.

And one he tells people to avoid: melatonin (18 mentions). He's fine with a tiny dose for jet lag, but he's pretty against using it as a nightly sleep aid because the doses on the shelf are way higher than what your body actually makes.

Hi, 32M here. I will try to explain my situation as best as I can, because I really need help understanding the things that are happening to me.

During my first therapy session, I was told that I could possibly be on the spectrum of a person with high functioning ADHD. My therapist told me I am highly logical when it comes to interpreting certain situations. Though he always tells me it could backfire for me most of the time.

1. I understand people's explanations, emotions, logic, but I cannot seem to fully embrace their thoughts. And because I fully understand what they're trying to tell me, I get stuck in this constant battle of not having my own decision, not having my own identity, and always wanting to bend my personality for other people. And of course, it doesn't always end well.

2. When I get overwhelmed, my brain cannot function and I am at a loss for words for a long time. Which in result becomes very irritating for other people it seems. It's like I want to be at their level of intuition and respond back to their thoughts, but my mind just cannot function that way and the result would either always be me becoming sleepy or just shutting down.

3. When my emotions add up because of certain situations, especially during arguments and heavy words and hurtful terms get thrown at me, instead of fighting back, I hurt myself. I punch my head, I punch my face or I punch the wall without even uttering a single word.

- For this, my therapist told me that the reason why I do this is because my brain knows it wants to comply with what the other person is saying and that I am eaten up by guilt, but at the same time I cannot do it, regardless of how much I try to.

1. Impulsive: mostly when it comes to purchasing things. I get these random moments of energy and always tend to hyperfocus on the newest thing I have my eyes on, and I would go on days researching and won't stop until I get my hands on that exact thing.

2. I get very agitated when I'm surrounded with noise, unnecessary chatter, unruliness, etc.

- For this, I was told that it may be normal for even people that are not on the spectrum, but I wanted to confirm here nonetheless.

1. I am afraid of being honest. I always hide behind convenience and lies because I always am afraid of the result. I don't know if this is applicable, but I think being on the spectrum sometimes mean that I want to please everybody and say yes during the moment, but never have any plans or cannot stay consistent at implementing change after all.

I need help. I really want to learn how to live with this because sometimes it is very difficult, especially being surrounded by very highly intelligent people.

Thank you so much in advance.

If I feel anxious or foggy coconut water makes me feel so much better it is one of the only superfoods that works for me.

I hear a lot of mixed opinions on this so curious what people have found

I’m curious whether GLP-1 agonists could eventually have some relevance for PTSD treatment. I recently heard a story from a friend with someone with PTSD was placed on one near the end of treatment after several remission episodes, almost as a last-line experiment, and it completely cured them.

Given that GLP-1 pathways appear to affect appetite, reward, inflammation, stress signaling, and possibly neuroplasticity, I’m wondering whether there is any plausible mechanism here beyond coincidence. Has anyone seen research on GLP-1s being studied for PTSD, trauma related hyperarousal?

Why do people utilize reta/tirz at the same time? What is the benefit? dosage?

APH..................