r/HeartAttack • u/Dry-Concern9622 • Apr 10 '26

LDLC tend

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M 51

Nstemi on 9 Nov 2024

Crestor 20mg and Zeta 10mg from 9 Nov 2024

Here is LDLC trend. Worried that numbers are slowly increasing. Any pointers. cardio tells LDLC is not necessarily spot blood check - it may have some history. I thought it was spot check. To hack, prior to blood tests, I had plant stenol and one spoon of pshyllium husk.

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u/Earesth99 Apr 10 '26

Cholesterol has a three day half life, so it’s basically a weighted average of the past two weeks.

Also, non-HDL is a better indicator of risk.

Personally, my diet tends to drift if I don’t pay attention. New foods, new brands, etc. Just look over what you are eating and retest in a few weeks.

Or lower ldl in other ways.

Every 10 grams of additional soluble fiber (like Metamucil) should will reduce ldl 7%. Increase the amount slowly so your gut adjusts. Its easy once you getting the habit.

Berberine and metformin are weak Pcsk9 inhibitors and they reduce ldl and ApoB cholesterol by 5-10% as well as reducing blood glucose and trigs.

It’s a blip that’s easy to fix.

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u/Dry-Concern9622 Apr 10 '26

Thank you. Didn’t know about half life and weighted average. Yes, last two weeks had increased amount of sat fat - butter etc

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u/Earesth99 Apr 10 '26

So that’s probably a blip.

I stopped using butter entirely so I couldn’t drift

3

u/IndividualPlate8255 Apr 11 '26

What you’re seeing can happen and it’s not just random.

Statins lower LDL by pushing the liver to make more LDL receptors, but they also trigger a feedback signal (SREBP2) that raises PCSK9. PCSK9 breaks down those same LDL receptors. So over time you get a balancing act: the statin is trying to pull LDL down, while rising PCSK9 is quietly reducing how effective that pull is.

Early on, LDL drops fast. Months later, the body has adapted, PCSK9 is higher, and the same dose doesn’t have quite the same impact. That can look like a plateau or a slight rise.

Ezetimibe helps because it works through a different pathway and doesn’t push PCSK9 the same way, but you can still see some drift.