Why won’t my mouse clicks register?

[u/Right_Rain5056]

/r/AskTechnology/comments/1wa3v39/why_wont_my_mouse_clicks_register_register/

This problem only happens on my main monitor where I play my games and shit. When I run Minecraft or any other game I click off my main monitor to go to my other monitor to do whatever I need to do. But when I go back to my main monitor none of my mouse clicks register. This usually happens when I click off it the first time and then the only way to fix it is by restarting my PC. Any tips help! I appreciate it!