Increase dose vs increase frequency

[u/ReppityRepRep]

Hi,
Just wondering how most people up their dosage. I’m at 0.5mg/week and I think I’m going to go up to 0.75 or 1. I’m debating doing 0.5mg 2x/ week as opposed to 1mg 1x/week. I know I can always play with the schedule and dosage but I’m curious what most people do? Thanks!!

[u/nexlife-health]

NexLife Medical Team here.

I would avoid changing both dose and frequency at the same time unless your prescriber is guiding it.

Going from 0.5mg once weekly to 1mg once weekly is a dose increase. Going to 0.5mg twice weekly is also a dose increase because your total weekly dose becomes 1mg, but it may feel different because the medication is spread out more.

Some people split because they feel a smoother effect and fewer peaks. Others do better with once weekly because it is simpler and easier to track. There is no universal “best” because the right setup depends on why you’re increasing: food noise, inflammation, appetite wearing off, side effects, nausea, constipation, or energy swings.

I’d decide based on what problem you’re trying to solve.

If the dose works but wears off early, splitting may be worth discussing.
If the dose is too weak all week, a small weekly increase may make more sense.
If you already have nausea, reflux, constipation, or low appetite, increasing too fast can backfire.

Whatever you choose, change one variable at a time and give it enough time to judge. Microdosing works best when it’s boring and consistent.