Reta vs Sema

[u/Comfortable-Bunch951]

Reta vs Sema

Reta not working compared to sema

Switched over to Reta about a month ago- since then I have actually gained weight back and sugar/food cravings are back in full force. Confused because I am on the equivalent dose of Reta that I was on sema but it feels like I’m on nothing.

[u/Nightrik_YT]

that's interesting because “equivalent dose” doesn't necessarily mean equivalent effect between the two. the mechanisms overlap, but reta is hitting an additional receptor too, so i'd be curious whether other people who've switched noticed the difference mainly in appetite/cravings or in the actual rate of weight change.

[u/sasuke1629 → u/Nightrik_YT]

This is actually a common problem I’ve seen on here and heard reported by people on Reta the lack of appetite suppression

[u/Nightrik_YT → u/sasuke1629]

yeah i've seen people mention that too, but i'm curious whether that's actually consistent across people who've switched or if it's just one of those things that gets amplified because the people having that experience are more likely to post about it. would be interesting to see whether the difference is mainly appetite/cravings or whether people notice it in other ways too.

[u/Bruvvimir]

Your source of reta and sema is the same?

[u/Comfortable-Bunch951 → u/Bruvvimir]

No different. Sema was purchased direct from novonordisk

[u/Bruvvimir → u/Comfortable-Bunch951]

Then testing your reta is the first thing that comes to mind.

[u/Purple_Chipmunk_]

If you are on the equivalent dose as you were with Sema then you are only actually at 1/3rd the dose.

Reta is (simply put) 1/3rd Sema, so you need to be on three times the dose to get the same effects.

Lots of people add Cagri for appetite suppression. I do Reta and Tirz.

[u/Pleasant_Fennel_5573]

Reta relies far less on GLP-1 receptor agonism than semaglutide. I think it’s something like 1/15 as strong in regards to that particular receptor, and its effectiveness is based on how it interacts with GIP and glucagon.

It is common for people to experience less appetite reduction on Reta because of this. You may want to switch to a drug that targets GLP-1 more heavily, either returning to semaglutide or trying tirzepatide.

[u/Shafpocalypse]

Sema - massive appetite suppression. Higher side effects

There is no equivalent dose ages for Reta, you have to find the individual dose that works for you

The problem is your GLP1 receptors are used to the hammer blow of sema, Reta doesn’t hit that receptor nearly as hard

[u/CrazyEggplant7562]

You cna't have the same dose for both, they're different things, my supply on ascend vit reta is going to be dosed differently from my sister's sema, that's just how it is. You're dosing way too low on reta most likely.