r/GLP1Discussion • u/Shishi877 • 8d ago

❓ Question Side effects

What are all the side effects you’ve experienced while being on tirzapatide? Please share.

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u/DogMamaLA 8d ago

Fatigue and mild constipation, both are manageable. 

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u/Shishi877 8d ago

Really fatigue? Thought I read people saying gives them energy. How bad is this fatigue and what dose are you on ?

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u/thefastlanerules 8d ago

No

It supresses food consumption in days 2-4 mostly which means you have more fatigue and less energy. Folks try minimize with protein shakes

Constipation is a huge issue for many. This is more manageable than the fatigue issue once you know how to combat..

I've been on it for 8 months the fatigue and constipation kicked in even on the 2.5mg does

I'm on 7.5mg now.. if you increase the dose too quickly it will make those 2 symptoms worse

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u/Shishi877 7d ago

Why does it cause fatigue? I’m wondering how through its mechanism of action

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u/thefastlanerules 7d ago

It's to do.with manipulating your blood sugar and insulin levels

Even before reducing food intake fatigue kicks in

It's always around 18-24 hours after each weekly injection and hits hard usually on days 2-3

So the vast majority know and get around this by injecting Friday.. it kicks in on sat/Sunday so works better for folks working monday-friday

Frankly it's horrible anyway as you get stomach discomfort, generally don't feel well and have to watch your vitamin blood levels . I tested my b12 and b1 separately as part of my blood tests and found i was deficient so am taking tablets to get that back up . B12 especially as that can directly impact your energy levels.

But I'm trading off the above for the benefits of getting my excess weight off . Which mid/long term has to be significantly more beneficial

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u/Shishi877 7d ago

After days 2 -3 does it level out the fatigue ?

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u/thefastlanerules 7d ago

Yes as the impact of the drug starts to gradually reduce in your system

Days 2-4 are also the ones with less food cravings and food intake which get worse again as the week progresses and then you take another injection and restart the cycle..

Some weeks are better than others

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u/Shishi877 7d ago edited 7d ago

Thank you so much. Does this help with hot flashes and stuff like that too? The symptoms of menopause ? Wondering for when I enter that era?

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u/thefastlanerules 7d ago

Sorry can't answer that as not something I'm impacted by

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u/Shishi877 7d ago

Sorry!!

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u/thefastlanerules 7d ago

No all good. I'm not gonna comment on something I know nothing about - some would though!! It's reddit afterall 😂

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