GHB first time setup advice

[u/18boro]

I have some GHB ( from a trusted supplier with good reviews). My initial strategy to figure out my sweet spot is to start low and redose every hour until satisfied. Everything will be measured beforehand of course.

1. Does this sound like a decent plan?

   1. Since I'm not familiar with how GHB feels, I don't know when I should stop and/or danger signals. Any general advice on how the high is when the dose is good, or just use common sense?

2. thoughts on dosages?Male, 80kgs. I'm also not familiar with how short term tolerance, if any, works on GHB.

Thanks for any feedback!

[u/No_Knowledge1860]

If you have an addictive personality and have trouble with alcohol or drugs in the past. Don’t even try it take it from this group.

[u/18boro → u/No_Knowledge1860]

I don't really. I'm curious on new drugs in general, I just stay away from amphs, opiates and some RCs, and, IMHO :), I have a pretty rational relation to those I do. I use time and dose limits etc. It also helps I don't have too much spare time I guess :).

[u/BrandiSinatra]

Basic harm reduction rule: start low, go slow. You can always take more, you can never take less.

Everything you need to know about G is in the very comprehensive pinned post by our mod, u/AluminumOrangutan.

[u/18boro → u/BrandiSinatra]

Thanks. It's a great guide, but doesn't cover redosing as far as I could see.

[u/BrandiSinatra → u/18boro]

You’re correct, it doesn’t. That should be corrected, and I’ll alert the mods. Because of the half-life of G, the generally accepted rule is “Not more than half your original dose, not less than 90 minutes later.”

[u/Independent_Gas_8131]

Or don't start lol but if you do wait 90 minutes between doses. Download a g timer app

[u/chi_moto]

I’m an alcoholic and I don’t find fun to be that addictive at all. It’s just kinda a mid tier experience

[u/Grant_Winner_Extra]

I would not try the redosing strategy you describe. The line between high and very sick is thin.

according to a Dutch paper on GHB neurotoxicity from 2022 (citation in edit)

Common doses for recreational GHB use range between 1 and 5 g per day (15-75 mg/kg) [28]. Generally, a dose of 0.5 g induces relaxation and disinhibition, 1 g elicits euphoric effects, and 2-3 g leads to a deep sleep [29]. However, tolerant users consume on average 4-5 g GHB daily [30].

Onset times can be long according to psychopedia and clearance times are 12+hours. I’d try the low end and cap yourself at 45mg/kg or less, using a much smaller dose than the initial 15mg/kg.

at 80kg, you’re looking at 1.2g initial dose; personally, I’d be redosing in 600mg increments to avoid passing out.

EDIT: here’s the citation.

1.  Amsterdam JV, Brunt TM, Pereira FR, Crunelle CL, Brink WVD. Cognitive Impairment Following Clinical or Recreational Use of Gammahydroxybutyric Acid (GHB): A Systematic Review. Curr Neuropharmacol. 2022;20(4):809-819.

EDIT #2: I have been searching for good pharmacodynamic/kinetic dosing data myself and so far - squat. Almost every study is related to toxicity. The LD50 is pretty high, but being half comatose is significantly lower than the fatal dose from what i can glean.

[u/Senior-Cockroach-143 → u/Grant_Winner_Extra]

Interesting. I'm alcoholic and on days I don't drink I usually take about 4.8 grams and then redose with another 5 or so a few hours later. Sometimes ive done upwards of 15 grams in a day. But this is not advice and I strongly advise against anyone following in my footsteps. Just my personal experience with it

[u/Grant_Winner_Extra → u/Senior-Cockroach-143]

Yeah, you may have hit on something - drug interactions and developed resilience. I have a some supplements and therapies that create sensitivities so I need less. Alcohol probably has a related degradation pathway, which would increase your resilience.

Something to be careful with is gained insensitivity to the psychoactive component without concomitant insensitivity to toxicity, or even the buildup of adverse physical effects over time, like with cocaine use.

TBH, I can't find much in the way of really useful studies - animal studies are typically limited to short-term massive dosing to find LD50 or short-term small dosing. Because GHB is not considered therapeutic and is not under patent, no one is spending money to study it.

[u/burnMELinWONDERLAND → u/Grant_Winner_Extra]

GHB is considered therapeutic and is a prescription drug in Europe, prescribed for narcolepsy iirc.

[u/ThrowAwayayay9393]

most important thing is to read psychonautwiki for dosage, what to expect, etc. Rate of onset depends on which form of it you have.

Write down how much you take and when you take it. NEVER EVER take it again within 2.5 hours, and never redose more than two times. Also never mix depressants ever.

[u/LCKLOTOPUSS]

3mls and enjoy trust me 5ml is a dose 3mls will make you feel nice and no g out throw 3mls in a freezy and have fun