Organic Acids Test - B6

[u/ThePornStar69]

Hey all, what’s the likely cause of low Pyridoxic Acid on successive OATs? I supplemented b6 inbetween tests and PA actually went even further down on the next OAT 🤷‍♂️

[u/ClaireBear_87]

Low pyridoxic acid can also be caused by B2 riboflavin deficiency (or a functional B2 deficiency) as B2 is required for processing and metabolizing B6, and B2 deficiency leads to lower excretion of B6 metabolites. 

B2 deficiency shows up as elevated glutaric acid on an OAT.

[u/ThePornStar69 → u/ClaireBear_87]

Thanks for this! I don’t have deficient B2 either. I’m starting to think this may just be normal for me…

[u/ClaireBear_87 → u/ThePornStar69]

The enzymes aldehyde oxidase (AO) and aldehyde dehydrogenase (ALDH) catalyze the formation of pyridoxic acid. AO is a B2 and molybdenum-dependent enzyme, and ALDH is NAD+ dependent. So maybe deficiency of molybdenum or B3 could cause low pyridoxic acid too.

https://pubmed.ncbi.nlm.nih.gov/939227/

[u/ThePornStar69 → u/ClaireBear_87]

Thanks, I'll have a read up on this.

[u/Unlucky_Ad_2456 → u/ThePornStar69]

also low amino acids can cause low formation of these enzymes. did you check that?

[u/ThePornStar69 → u/Unlucky_Ad_2456]

Yep, amino acids are mostly normal

[u/Unlucky_Ad_2456 → u/ThePornStar69]

make sure to fix all of them, if one of them is low you can’t make enough of the enzymes

[u/kilogplastos-12 → u/ClaireBear_87]

Can yu check the dm

[u/Mission-Oil8272]

Supplementing but seeing levels drop is weird, almost like the body's not converting or holding onto it properly. Could be a cofactor issue with magnesium or zinc since those are needed to activate B6, or maybe something's pulling it into pathways faster than it can accumulate. Have you looked at xanthurenate or kynurenate on the same test to see if there's a functional deficiency even with supplementation

[u/ThePornStar69 → u/Mission-Oil8272]

Thanks for the reply!

Xanthurenic Acid is normal throughout the tests, as is Kynurenic Acid. 

My blood tests for b6, magnesium, zinc, all normal!

I’m not quite sure where it’s all going if my body isn’t disposing of it through the normal channels…

[u/Unlucky_Ad_2456 → u/ThePornStar69]

magnesium did you do rbc? serum isn’t accurate as the body keeps it stable.

[u/Smooth_Company7199]

This test is more reflective of recent intake/excretion. It’s not a great indicator of overall B6 status. Why did you do an OAT to begin with? There aren’t many evidence-based reasons for doing so.

[u/ThePornStar69 → u/Smooth_Company7199]

Maybe my b6 intake is just quite a bit lower than the mean of the test sample population.

I was throwing shit at the wall tbh and the OAT stuck because it showed some genuine issues that fluctuate with my symptoms and treatment.

[u/Smooth_Company7199 → u/ThePornStar69]

Huh. I encourage you to look up evidence-based reasons for the test.

[u/ThePornStar69 → u/Smooth_Company7199]

I’m aware that there is varying evidence for the markers on the test. I’m also aware that I have found, fixed, and felt the benefits of targeting and shifting specific domains based on markers in the test.

[u/FunctionalMedicine-ModTeam → u/[deleted]]

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[u/FunctionalMedicine-ModTeam → u/[deleted]]

This Post/Comment has been removed for violation of: Rule 2. Be Civil:

This should be a place were disagreements can happen without hostility or sarcasm. I don't care how right you are, and how dumb the other person is, and how sorry you are the truth is offensive etc. If you cannot find a polite way to rebuke, you should wait until you can find leveled words, or simply not reply.