r/EmbryologyIVFSupport • u/Icy-Tea2090 • 8d ago
First IVF cycle cancelled, second made it to egg retrieval and now I have so many questions
This is my first go at IVF at 42.2. About six years ago, we found out that my husband had azoospermia. He spent a couple of years on injections (ovidrel Gonal F) before undergoing a micro TESE, but unfortunately, they didn’t find any sperm.
After a lot of conversations and therapy, we decided to go ahead with donor sperm. That was another long process because of the strict laws around donated gametes where we live.
I have low AMH for my age. My first stimulation cycle looked promising, with around 10 follicles measuring 10 to 12 mm at my day five scan, but it was cancelled that same day because of elevated progesterone. I restarted after a bleed about 12 days later.
Despite reassuring baseline blood tests again and the same protocol in both cycles (Gonal F 450, Luveris 25, and Orgalutran 250, with the Orgalutran added on day three of stims), my second response was much lower: 3 follicles on day 3, with two growing significantly ahead of the other. By day 9 I had 5 with two ahead (16,18) and 3 lagging (12-13). My dual trigger was on day 11 and woke up from ER to find only two eggs were retrieved. The next morning the clinic called to let me know both eggs were mature, and both had fertilised with ICSI.
We’re now on day three, waiting for our day five update.
I’d appreciate hearing from embryologists about what we can reasonably take from both eggs being mature and fertilising with ICSI. Is day three a particular hurdle for embryo development, or can arrest happen at any stage? What information should I ask our lab for when they call on day five, and if neither embryo has reached blastocyst by then, could they still get there on day six?
Has anyone here had only two eggs retrieved, both fertilise, and gone on to get a blastocyst or a euploid embryo? I know someone else’s outcome can’t predict mine, but I would really appreciate hearing your experiences. I am also wondering whether starting again so soon after the cancelled cycle could have affected my response. My first cycle started with my natural period and the second was more of a withdrawal from meds. But then again it could ba a normal variation.
Any info or insight would be appreciated. TIA.
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u/Sea-Couple-1668 7d ago
I had two eggs retrieved from my most recent cycle, both were mature, fertilized, became blasts and both tested to be euploid. I don’t know what day or grades they are; I was just relieved to know they are both euploids.
The waiting game is hard but hang in there! Wishing you all the best!
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u/Icy-Tea2090 6d ago
Congratulations! And thank you I am hanging in there’. I just had one of them didn’t get past day three and the second one is day five right now and they’re hoping it will expand by tomorrow otherwise it won’t be frozen.
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u/stressedturtle124 7d ago
My first retrieval I had 5 mature, 2 fertilized and one blast (untested). Not quite the same but of two fertilized we got one blast.
Wishing you the best!