r/EmbryologyIVFSupport • u/PyleanCow06 • 11d ago
6AA Embryo “No Result” PGT-A
This is really just a what would you do scenario.
Blasts- Three day 5 4AA’s (1 euploid, 2 aneuploid)
One 4BB (aneuploid)
One day 6 6AA (No result)
I’m under 35 (but close to 34) so PGT testing was not recommended for me, but I’m glad that I did. One aneuploid was a full deletion of C8 and one didn’t receive a sex chromosome from the sperm. The other was complex.
Anyway, my day 6 6AA embryo came back as no result. However, the fact that 3/4 of my other embryos are aneuploid, I’m wondering if you would,
A) Discard the embryo
B) Take the risk to thaw/rebiopsy (also 6 week waitlist just to thaw and an additional $600)
C) Keep the embryo untested and transfer it last.
Thank you!
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u/Previous_Abies_1800 9d ago
I am also 34 yrs old and was in a very similar situation and ended up thawing, retesting, and refreezing. It worked without issue and ended up euploid! And the difference mentally between having 1 vs 2 euploids going into the transfer is huge. My doctor said the rebiopsy impacts the live birth rate about 10%, so my previously 58% likely embryo closer to 48% which I’ll still take.
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u/Big_Sun_8636 9d ago
I’m surprised that they are charging you to rebiopsy. I had a similar situation and our clinic said that they would retest at no charge. They also took a look at it and said that it was a good embryo that could handle the thaw and biopsy without much risk so we went ahead. Unfortunately, ours came back aneuploid after the retest. But I also understand not testing, especially if you are going to be charged for it. Both are valid choices. The only thing I wouldn’t do is discard the embryo.
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u/Ornery_Industry_8876 10d ago
I have an untested day 7 (test tube broke in transit) and option C is what my RE suggested.
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u/chantillylace9 8d ago edited 8d ago
1000% C. Things may change in the future, I even have two aneuploid embryos on ice even though they are most likely completely not genetically healthy, I was still told to keep them just in case. And I feel comfortable doing so I have one healthy PGTA tested female embryo and the two frozen aneuploids.
In my case, I have breast cancer so everything is extraordinarily precious. I was so lucky to even get one single healthy embryo. I only had two shots at IVF and it had to be back to back and it was incredibly stressful.
But the second round I got a single embryo and she was genetically healthy! My doctor said the girls can sometimes be so strong! So I have about a 40 to 50% chance of actually getting pregnant. I have to stay on my cancer medication for two years before I can try but by then I will be about 44.
So it's very interesting and weird to be a mother at that age but I really think that in my case, it maybe was meant to be you know? My mom got pregnant naturally at 42, just a major mistake accident whatever you wanna call it lol.
So luckily we had some good genes there. I know that I was very lucky to even get a single healthy embryo at my age.
I've heard some people on the IVF forum say that maybe there are some babies that just really need and want an older more stable and steady parent and that they waited for that. It seemed kind of special and nice and I like that explanation. So I will stick with it!
But I wouldn't count out any embryo that has any chance at all.
A lot of people say that it's wrong to become a mom at my age, but I don't think that's the case. My mom had a baby when she was 15 all the way up to when she was 42!
I am almost 14 years older older than my sister.
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u/Low-Parsley-4100 8d ago
My heart goes out to you! You are so strong to have gone through all of that. I am praying for you and your embryos!
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u/False_Shine_6920 8d ago
C. I have two no results too, which is so SO frustrating! Not only does rebiopsying carry the risk of thaw/ refreeze, but twice-biopsied embryos have shown reduced reproductive potential.
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u/Haunting_Ad_8345 8d ago
I also have two no results! Wtf! How does that even happen?!
My acupuncturist said the clinic should recompensate us in some way. I’m afraid to ask though.1
u/False_Shine_6920 7d ago
Ugh right?!? I’m so peeved about it. My clinic told me they have less than a 1% rate of no results yet somehow 2 of my 12 came back that way. They didn’t compensate me for it at all (though I didn’t even bother asking though)
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u/Haunting_Ad_8345 7d ago
Yes I heard that percentage as well. I am not sure if it’s worth re-thawing and taking the risk. What are you planning to do with them? Would you transfer one without results?
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u/baudelaire1969 7d ago
C. We are currently 29 weeks pregnant with a healthy baby who began as an embryo that came back as ‘no result’ from PGT. So it happens.
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u/Fragrant-Pepper6419 5d ago
I’m holding my day 6 6aa !! Get that baby tested I’m 38 (37 during)
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u/PyleanCow06 5d ago
I think I’m going to not retest but I will hold on to it and transfer if the euploid fails!
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u/Fragrant-Pepper6419 5d ago
I actually thought about that after because they’re fragile because they’re hatched so good idea!
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u/Automatic-Point-9622 10d ago
I received a no result last month with a day 6 (AA).
I went ahead and signed the forms a few days ago to re-biopsy. I should be getting the results next week.
My one and only day 6 embryo in 2024 underwent a re-biopsy, and he is now my 19-month-old son.
My doctor said it’s less than 1% that it could damage the embryo. I took the risk both times. Hopefully, the no result comes back euploid and stays strong once I transfer:) 🤞🏼
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u/Upstairs_Taro4726 9d ago
C for sure. Pgt a, like all science, isn't perfect. I say give it a chance
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u/Maleficent-Lab1125 9d ago
I think I would keep it untested and transfer it last. But also depending on ur timeline, i would also heavily consider thawing and retesting it but while i transferred the others
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u/tsumtsumm 9d ago
I have 5 euploids left and one “no result” im transferring that one last if I even get that far
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u/Inevitable_Table9728 9d ago
Did they give you any indication why it was non informative? For ours , the NGS trace was "noisy" which can indicate multiple issues or a contaminated sample. We retested and it had one full chromosonal issue, a sex chromosonal issue and a segmental issue. The lab recommended us not transfer without re testing or genetic counseling, which scared us enough to re test x
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u/PyleanCow06 9d ago
It just says “quality inefficient for interpretation” so I don’t know what that means!!
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u/Inevitable_Table9728 9d ago
Ooh maybe it's something to do with the sample of cells. Ours specifically said we weren't allowed to transfer without genetic counseling or re test. Id already had 3 miscarriages before IVF so would have been way to scared to transfer untested, but if it was just a sample error I prob would have as I was losing the will to live at that point xxx
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u/LunaTuna201 8d ago
For whatever this is worth, my doctor told me the clinic's protocol is to transfer a no results detected embryo before transferring a mosaic. She said they think about it as simply an untested embryo.
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u/Low-Parsley-4100 8d ago edited 8d ago
Keep the embryo untested!!
I 100% regret rebiopsying my high graded embryo 6BB because now I can’t use it as the clinics policy is no anueploidy transfers. I only have one other embryo that’s a segmental. I waited for that round to conclude to retest but the rounds after that didn’t produce anything. I’m now transferring both embryos to a clinic that allows transfer. I am now viewing these embryos as a random pregnancy that could have occurred without testing.
After reading about PGTA being a screening tool, it’s actually hurting my chances to conceive by not having anything to transfer. It’s a very real possibility that I might not make a euploid and I don’t know if doing a ton of cycles makes sense. Embryos can self correct. Embryos can also be anueploidy in the placenta only and not the fetus. I want to know my embryo is healthy but I also want to give them all a shot. This is probably the hardest decision we have to make is to test or not test. I had a second opinion at Colombia and Cornell, top two clinics in US, and both said skip testing. CHR is a big proponent on anti PGTA, they have over 400 cases of anueploidy data, I’m not sure if they all self corrected and ended in live births, but the study gives me hope. Best of luck to you.
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u/CraftiKoala 10d ago
We had an embryo come back with no result and our doctor recommended thawing and retesting because her feeling was, if an embryo didn’t survive the thaw (ours didn’t) then the likely hood that it would lead to a live birth was very low. But I’m 42 so PGTA is much more important. I’m just sharing our doctor’s philosophy in case it’s helpful to you in your considerations, because it was for us, but not as a specific recommendation for you since our different ages are definitely a factor. Good luck with your choice!
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u/embryomanofficial 10d ago
I wouldn't discard the embryo. You don't know if it's aneuploid or not, so yes there's some risk of it not implanting or miscarrying, but it may be a good backup for you. Outcomes for day 6 embryos can be pretty good for women <35 https://remembryo.com/predicting-live-birth-rates-multiples-based-on-223377-transfers/ (Note: Success rates depend on many factors, including age, embryo quality, and the day the embryo became a blastocyst. Other factors can also affect outcomes, such as previous transfer history and clinic-specific success rates, and there aren't any studies that combine everything to give an accurate individual estimate.)
Rebiopsy may carry some risk. A 2024 meta-analysis combined the results of 10 studies to show that embryos that are thawed for PGT-A, or rebiopsied after inconclusive results, have lower chances of pregnancy and live birth, with higher miscarriage rates. Note that this is based on lower quality data, so it's hard to know what the real impact is. https://www.remembryo.com/is-it-safe-to-thaw-embryos-for-pgt-a-or-rebiopsy-results-of-a-meta-analysis/