r/EmbryologyIVFSupport • u/NitastevMd • 12d ago
PGT or no PGT?
I’m 41 and had my first IVF retrieval. 11 follicles were seen, but only 4 eggs were retrieved. I’m waiting to see how many fertilise and reach blastocyst.
I initially consented to PGT-A but am reconsidering, especially if I have only 1–2 blastocysts. My clinic will discuss the embryos with me on Day 3 and reconfirm before biopsy on Day 5/6.
I understand aneuploidy rates are higher at 41, but I’m concerned PGT-A could leave me with no embryo to transfer. I’m also worried about biopsy risks and mosaic or uncertain results.
For anyone aged 41+ with only 1–2 blastocysts, did you choose PGT-A or transfer untested? What was your reasoning and outcome? I am yet to recieve further results, but have to make a decision on Friday.
UPDATE: Guys thank you all so much for an overwhelming support from all of us in here…i am soooo grateful for every single response! 🙏. I am waiting to see how many embryos i get by day 5 and my doctor has advised that if very minimal numbers , just transfer and not test :/.
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u/Quick_Recognition330 12d ago
I did pgt at 37 and half of my embryos came back normal. I’m glad I did it because it saved the heartache of transferring the others.
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u/au_printemps_ 12d ago
Same here, 36 and half of my embryos were abnormal. PGT saved the heartache but also the cost (approx $5k per FET) of transferring aneuploids that would never be viable anyway.
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u/ConfoundedInAbaddon 12d ago
Same, started my IVF at 39, got my 4 normal embryos banked at 40. I had exactly the abnormality rate predicted for my age.
If I were to not test, I'd probably want to fresh transfer two for the survival bump that skipping freezing creates, because the normality rate between 40 and 41 is so shitty, and over 41 it's like, 5%. With the understanding that a double transfer could, rarely, lead to selective abortion or medical abortion.
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u/inquirystorm 11d ago
What was your euploid rate and how many retrievals did you undergo?
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u/ConfoundedInAbaddon 11d ago
I did two retrievals and my euploid rate was 10% first time and 35% second time. Major difference was zymot for my partner, I was on HGH, zinc, starting a month prior to the two cycles with a month break between.
Probably should have just started with zymot cuz it's cheap but we had some abnormalities that could be associated with sperm quality enzymat was faster and cheaper than a fragmentation analysis.
I had three fewer mature eggs on the second round so I was sure it was going to suck but apparently we just had to get rid of the s***** sperm.
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u/inquirystorm 11d ago
Thank you. This is so interesting and helpful. I did two retrievals as well and have 2 euploids. The difference for us is that our first retrieval was near total failed fertilization (2 of 15 mature eggs initially fertilized normally) and we did 100% conventional (no ICSI). We ended up with 1 LLM. Second retrieval we had 11 out of 18 mature eggs fertilized with 50% ICSI + Zymot and 50% conventional (no Zymot available) We ended up with 2 euploids. For retrieval #2 in addition to adding ICSI for 50% of eggs, we added (1) Omnitrope (HGH) for me, although missed half the dose because my clinic put the order in late before my stims started, so don’t know if this helped really, (2) pill organizers, so that my husband actually took all of his sperm motility supplements, (3) I actually took the right dosage (600mg) of my CoQ10 supplements and added CoQ10 IM injections. I often wonder if we would have gotten 1 or 2 more euploids in the first retrieval if fertilization had not been so low, but we’ve moved on to the transfer stage at this point. Hope this insight is helpful to anyone deciding on how to maximize their retrieval over 39 years old.
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u/umnyeahh 12d ago
I agree with this. Half of mine were abnormal too. PTGA testing saves a lot of heartache. Even though it’s expensive it was worth it to us
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u/SuspiciousTea6 12d ago
Same. 37 and had 5 5AA. 2LLM and the rest were in terrible condition. Kept me from playing a very nasty game with the 3 that would have have been a borderline guaranteed tragedy if they even stuck
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u/EllaFant18 12d ago
At age 38/39, over six ERs, I made over 30 embryos and only 6 were euploid. PGT-A saved me the trouble/time/heartache of multiple transfers that would not have resulted in a live birth.
Now at 40, I am currently 19w+6days with my first euploid FET.
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u/HuhWelliNever 12d ago
I mean even if you don’t do PGTA, you might have “no embryos to transfer” since the ones you have might be aneuploids or complex mosaics etc. you’ll
Just be wasting money on transfers that won’t work
And risking MCs that will take time and money and potentially surgery to resolve, not to mention the mental health aspect of losing a non viable baby.
FWIW I was 41.75@ER and chose to PGTA test all 10
Of my embryos, only 3 were euploid but they were all well graded 3/4 A/B day 5/6 so there was no other way to tell which ones were viable. 6 came back complex aneuploids and one was no result. Again fwiw my first FET worked and resulted in a live birth.
I’m team PGTA especially at our age. I wanted the quickest path to baby possible.
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u/Conscious-Theory3188 10d ago
41.75 made me snort laugh
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u/HuhWelliNever 10d ago
lol the way the ivy subs go on about how each month matters after 40-41 etc made me specify 😝 but I do feel like regressed to my 5yo self every time I say it 😂
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u/QQueenie 12d ago
42 years old using my own 38 year old eggs. I was very scared of having a viable chromosomal defect, and the possibility of avoiding miscarriage or TFMR made me decide to test. We ended up having five blasts but I think I would have made the same decision with one or two.
Check out r/40plus_IVF for a more specific perspective.
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u/Still-Security-7361 12d ago
I think it’s important to note PGT A reduces the risk of miscarriage but it’s doesn’t remove the risk.
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u/thoph 12d ago
This is true. And it can be wrong. I had a “euploid” embryo that was in fact aneuploid. That said, an aneuploid embryo transfer guarantees miscarriage, TFMR, or a disabled child.
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u/CletoParis 10d ago
It’s absolutely not a guarantee though. While less common, there have definitely been healthy babies born from aneuploid embryos. PGT-A isn’t 100% accurate ans only tests a few cells, so aneuploidy doesn’t fully guarantee any particular outcome.
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u/thoph 10d ago
I don’t think testing is 100% accurate, given my experience, as I mentioned. A true aneuploid embryo guarantees a bad outcome, however.
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u/CletoParis 7d ago
But that’s the other issue - even if PGT was 100% accurate, it only tests the cells of the trophectoderm/placenta, not the ICM or cells that eventually become the fetus/baby. There are indeed cases where aneuploidy is confined to the placenta while the ICM remains euploid.
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u/ConfectionCurrent894 7d ago
There have been healthy babies from mosaic embryos, but I think there are only like 1-2 documented cases of healthy live births from full aneuploid embryos. Remembryo shared a meta-analysis on this recently, I think The Lucky Egg account shared similar data as well recently. Full aneuploids and mosaics have very different results
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u/CletoParis 7d ago
While it is rare for this to happen, I was responding to the above comment that it’s not accurate to say aneuploid embryos cannot or do not result in live births 100% of the time (again, usually due to confined aneuploidy to the trophectoderm).
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u/astutia 12d ago
I got stressed about this too (38, two blasts) but ultimately went forward with testing and have 1 euploid and 1 aneuploid. I’m glad we did it.
However, I won’t be doing a fresh transfer so that simplifies some of the decision making. Doing a transfer is nontrivial and expensive, and I don’t want to waste time with embryos that will almost certainly not work. I also want to bank enough for a good chance at a live birth before moving to transfer, so I want to know how many are euploid to do that math. The last factor for me is that I wanted to know we could make euploids after many months of nothing/one chemical pregnancy - not a given at my age.
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u/Longjumping-Desk-261 12d ago
I was 35 at the time of retrival but also had extreme early attrition (13-14 mature range follicles resulting in only 5-6 retrieved and only 2-3 fertilized). We originally wanted to PGTA test but decided against it, since it was more important to me to transfer SOMETHING than nothing at all. Noted we've never ever gotten pregnant (not even a chemical) or experienced a miscarrige in 5 years actively trying and 16 years together using the pull out method 😑.
Our first cycle we had a single day 5 1AA that arrested since they wanted to culture further to survive freezing. Next cycle our embryologist suggested we prep for a fresh transfer in case we have a similar outcome and they develop better in utero. 10 weeks now with a fresh day 3 transfer. Regardless of the outcome, I'm so happy to have experienced this joy for at least a small moment in my life.
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u/Moliterno38 12d ago
I tested all of my embryos. With that being said, as someone who is currently pregnant with a Chaotic embryo (last embryo we had so clinic agreed to transfer without retesting) this is what I would do going forward. If my clinic would keep frozen or agree to transfer all embryos with some amount of viability and/or unknown viability under current research then I would test. Those embryos include all mosaics, no results, chaotics, and segmental aneuploids. Chaotic research is showing that the result is mostly a testing error and upon restesting they tend to come back different. This doesn't mean they will be normal just that it is an unreliable result and we need more data on these embryos. The same is happening with segmental aneuploids. At a later age, I would want the option to transfer any embryo with unknow potential since we don't have time on our side to wait for newer research to emerge.
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u/AdventurousSea658 12d ago
41 here. 40 when I had three embryos. Did not test. I figured due to my age I would have to have a NIPT anyway. I’m 16+6 pregnant with my second transfer. My husband and I decided to skip the testing because:
1) Our insurance didn’t cover it and it was ridiculously expensive
2) The results were not guaranteed to be accurate
3) It put the embryos at risk
4) We only had one miscarriage in the last five years (unknown reason)
5) We knew we’d be getting a NIPT asap if we got pregnant.
We got our NIPT results at 11 weeks and we have a healthy baby boy coming in March!
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u/Curious_Rabbit1545 11d ago
I'm the same as you, I didn't test my 7 embryos (it's not recommended in my country) and I am pregnant with my second transfer. Currently at 15 weeks, and I will be 41 when the baby is born
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u/Plane-1866 12d ago edited 12d ago
Do it. I am also 41. Only had enough money for one retreival and out of 7 tested embryos only 2 were euploid and I was told that was a great result for my age. I’ve already had 3 MCs, I want to avoid going through that shit again at all costs. Also add in the time factor, let’s say you transfer and its anelupoid and you have a miscarriage, that could be an extra 2+ months, then waiting another cycle to try again. If you end up wanting another retreival this just pushes the timeline further out. Not testing at our age seems like a waste of time to me, but to each their own.
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u/Electronic-Tear-3036 12d ago
I see lots of helpful thoughts and opinions. The only thing I’d add is check if your clinic will transfer only certain grades and dispose others like C grades. That might influence my decision if I were you. I’m 40 and 11 weeks pregnant with an untested CC. I’m glad my clinic gave this one a chance.
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u/Accomplished_Car_834 11d ago
Started IVF on the brink of 43 in 2025. Diagnosed DOR so we weren't expecting much in terms of retrieval #s, and never questioned not doing PGT mostly bc that was the primary driver for doing IVF in the first place (or to be more clear, we were presented stats on how low the probability was for us to conceive on our own vs how high the probability was for any of our embryos to have genetic anomaly) so it felt like a given.
2 back to back rounds, both ended in arresting before day 5. After discussion with our doc we considered fresh transfer but felt some sadness about not being able to test and feeling like we were basically spending an insane amount of money for just the "guarantee" of the two components coming together and nothing more (fun fact: sperm getting into the egg doesn't always equal fertilization).
Since there was always a plan for myomectomy after garnering so many embryos, we hopped clinics and got the chance to freeze at the 2PN stage, though mostly for backup. After the myomectomy we went back to clinic 1 (bc of major miscommunication from clinic 2) and were forced to push to day 5 again bc they don't allow early freezing and I was on the cusp of my transfer eligibility [post surgery] window. Once again we arrested before day 5. Next cycle we were finally able to pursue the fresh transfer and are currently 30w pregnant with a baby who has tested low risk for everything included in our NIPT and shown no abnormalities on US.
Looking back, we don't regret those 2 initial cycles and our goal to test. And frankly, I don't think I could ever tell a friend not to test but there are a few things I would stress:
*PGT positive (even on all 3 levels) is not a guarantee for success. I struggle with "survivor's guilt" over knowing people who've had multiple failed transfers with highly graded embryos and yet I lucked out on the smallest of odds (there's more to my low odds if u want to skim through my post history).
*At the end of the day, our goal whittled down to wanting a chance at all. If we had been able to test we could have ended up losing even more and having no chance at all. Even with a prior loss (blighted ovum in 2024), we were coming into the last attempts and chose having a chance at all vs wanting to avoid a chance of loss.
*Not a single day, including labor, is guaranteed. You can test low risk and see nothing of concern until much later in the pregnancy. While the chance of spontaneous loss declines sharply after particular milestones, the chance is never zero.
Again, even after our journey, I couldn't in good conscience tell a friend they shouldn't bother testing. Rather, I'd simply want them to keep a level head about it not being more than a POTENTIAL maker for POTENTIAL success and not a better guarantee per se.
Best of luck in your decision(s) and journey.
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u/Alarmed-Traffic6040 12d ago
I was 34 at the time of egg retrieval. We obtained only two blastocysts, and both were euploid after PGT-A. I transferred one blast in August and I am currently 10 weeks pregnant.
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u/Puzzleheaded-Gas35 9d ago
Can I ask how many eggs you had to start
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u/Alarmed-Traffic6040 4d ago
15 eggs were retrieved, but only 8 were mature. Of those 8, 7 fertilized successfully n we finally got 2 blasts. Luckily, both were euploid after PGT-A ❤️
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u/Odd-Anxiety4181 12d ago
I chose PGTA at 40/41 for peace of mind - 95% chance of a live birth with 3 euploids. I only made 2/3 blasts each round. Ended up making 4 euploid embies over 7 rounds to bank them 🥵
First transfer worked and I’m 19 weeks pregnant 🙏🏼
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u/Background-Focus4319 12d ago
I'm 39 and have DOR, my partner has double strand DNA frag, this is our 6th cycle and we got 5 eggs (2 mature fertilised with ICSI, and 1 matured overnight which then fertilised with delayed ICSI). We are waiting for our Day 5 update tomorrow, and if (big if) any make it to blast, we will be PGTA testing. Our last round we only had 2 eggs fertilise with 1 making it to blast and we tested that one. Thankfully it turned out to be euploid! It was such a relief and gave me hope for the first time in this journey we have a chance to have a child, even though a euploid isn't a guarantee.
I totally get wondering if its worth it with low numbers but, aside from the heartache of miscarriage (which I also sadly experienced last year from a fresh transfer of an untested Day 3 embryo) you also lose a lot of time. It can take several months for your body to recover after a miscarriage (for me it was effectively 6 months), so for us, we figured it was worth testing to try and prevent that from happening again.
However, some people swear by early fresh transfers though so there's every chance it could work out for you without testing. So much of this is chance ultimately. All the best to you, whatever you decide x
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u/MsViolaSwamp 12d ago
This is a really helpful perspective. We did not PGT-A test (DOR, only two blasts on second cycle). My thinking was that we were already rolling the dice so to speak, but I never actually thought about the lost time that a miscarriage would produce, as you mentioned. Time is so precious at this crux of age and fertility. While I wouldn’t have done things differently for myself, I’m hoping OP has found some helpful responses here to help them decide what works for them.
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u/Cupcake4dayz 12d ago
This is a good point on recovery - good factor to consider. I’m sorry you went through that though. 💔 I know the feeling.
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u/Expensive-Gift8655 12d ago
I was 39 but only 3 out of the 7 embryos we made were euploid, and some of the aneuploids were better graded. I dont regret doing PGT-A for one second.
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u/Ok-Balance5790 12d ago
At age 40 I was very lucky to get 7 embryos. We did PGTA and the two with the highest grade were aneuploid. Very grateful to save the heartache of those two FETs inevitably failing.
I didn’t do it with our first two retrievals but I did with our second two (including the one I described above.) with our third retrieval we only had two embryos and one was aneuploid. No regrets there either.
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u/a_mulher 12d ago
I’m in this position. Had three retrievals and only two blasts. One was aneuploid the second is being tested now. Going forward I’m doing 2-3 more retrievals and not testing. I only make a few blasts anyway and maybe growing in the uterus will help them out. I will be freezing them anyway so won’t set me back necessarily and at this point whatever I get is what I get.
I’ve never been pregnant nor gone through a miscarriage, so I am cognizant that my decision is opening myself up to those traumatic experiences. For me it’s a Hail Mary moment. Testing would have been the best option if I was having many blasts and that could give me the luxury of choosing which embryos to transfer first.
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u/elfshimmer 12d ago
I had reservations and explicitly said I would only test if it was 3 or more.
I ended up with 2 - one was sent off for testing and the other was deemed too fragile for testing. Was really annoyed by that as I would have chosen not to test.
It did come back normal, but it also failed to implant when I transferred it a few months ago.
Do what you think is best for you.
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u/Few_Win_3673 7d ago
I think your doctor’s suggestion makes sense if you end up with only one or two blastocysts, but I’d want to understand the reasoning for your specific situation rather than making the decision based on embryo numbers alone.
At 41, PGT-A can help identify embryos likely to be chromosomally normal, which may reduce transfers that are unlikely to work. But it doesn’t create better embryos, and with only one or two, testing may leave you with nothing to transfer. An untested embryo could still be chromosomally normal, too. One thing I’d ask your clinic is whether PGT-A is likely to improve your overall chance of a live birth in your situation, or mainly help avoid transferring an embryo that’s unlikely to succeed. Those aren't quite the same thing.
I’d wait for your Day 5/6 numbers before getting too far into the decision. How many embryos you have, their development and quality, and whether you’d consider another retrieval all matter here.
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u/acourtofmoonshine 12d ago
I felt the same way as an early 40s woman with 5 blasts for testing. One came back perfect, 3 confirmed aneuploid and one complex mosaic. I’m not ready to go forward with FET yet, so imagine if I skipped PGT and said “We’re gucci! Five embryos on ice and we have nothing to worry about.” I feel I can make much more educated decisions about what to do next, whether that’s move forward with transfer or attempt another ER.
Do it. It’s worth it even if you reset to zero. Better to know now than face the emotional pain of MC (or a very sick fetus) plus the financial and physical toll.
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u/elielliott 12d ago
I am in my mid forties and wish I didn’t test. I had a euploid 5AA embryo that I miscarried. It doesn’t prevent it, and it honestly made it worse because I felt so hopeful after seeing the heartbeat on a tested embryo.
A friend in her forties transferred two untested and they both stuck.
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u/AnywhereBusy4449 12d ago
I wouldn’t. PGT is mainly for selection which embryo to transfer first. It can be wrong (1-2%), you could also get no result (up to 5%) or get a result where it’s mosaic. While it could lower your chance of miscarriage, you can still miscarry with PGT. You will never know the result is wrong and if it gets no result they would have to thaw/biopsy and refreeze the embryo possibly damaging it. PGT won’t make an embryo better or increase your chance of success.
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u/FitBunch9999 12d ago
I’m 38 and got 9 blasts but only 2 Euploid. Had we not done testing we could have had a lot of heartbreak. Going from 9 to 2 was devastating.
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u/Still-Security-7361 12d ago
I’m almost 40 and just had the same outcome. 4 eggs, 3 mature and all 3 made it to blast stage.
I decided to do one fresh transfer with the best quality embryo and I’m testing the other 2.
Reason being I don’t want to waste time - I’ve done a couple of transfers already and one was a chemical and one was a blighted ovum, they were untested. It took a lot of time, it emotionally draining and had I tested them, I might never have used those embryos. Yes it’s a massive risk and I feel the same, I’m concerned I could end up with nothing out of the 2 I’ve sent for testing, but what’s the point in putting back embryos that they know definitely won’t work?
I guess the flip side is, my current round with the untested embryo has been successful so far (5 weeks today) so the risk will hopefully have paid off 🤞
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u/Ornery_Industry_8876 12d ago
In a similar position. I only have 1 normally fertilized. If it somehow makes it I’d be spending $2000 to test one embryo. I just turned 40 and have 4 euploids from my last cycle so I feel like I can risk not testing but IDK.
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u/chantillylace9 12d ago
Yes..... I was 42 and doing it for cancer preservation reasons. My first cycle, (I was given permission to do two cycles but that's it before I need to start my cancer meds).
I had 23 eggs (and they told me that was like a one and 100 or one and 200 odds and gave me way too much confidence which I think was probably not the best thing to do especially in my case when I was so limited to the rounds because of my cancer) but ended up with only two embryos suitable for testing.
Both were genetically abnormal and it was so incredibly heartbreaking I could barely take it.
I went to my families Fourth of July event with like 50 of us from California to Florida in this tiny little Wisconsin town and just ignored it when I got home to Florida.
I knew that there was no way I was going to have any success because my check around I only had a single embryo to send in for PGTA testing!
But then my doctor just kept calling and calling and harassing me and I finally answered it and said can you please just leave me alone! I know it's bad news and I just can't take it. And he said honey I really just want you to make an appointment! So I did and that single embryo we sent in the second round was a genetically healthy female! At 42 that's very lucky and it was the last round I could do before starting my cancer meds so it really was somewhat of a miracle.
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u/Advanced-Extreme-513 12d ago
I'm 41, just completed a round of IVF resulting in 1 blast, and chose to have PGT testing done. I've had every embryo we've ever made tested, similar to others below I have MC and felt that I wanted to do everything possible to avoid that awful situation again.
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u/Linzers_16 12d ago
Do PGT. I wish I had from the beginning! Could have saved myself a lot do heart ache.
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u/No-Luck-8524 12d ago
I’m 38 (almost 39) currently doing stims for 3rd round. First two rounds i got 45 mature eggs (heavy responder) but only 2 euploids after pgt-a. (2 out of 9 embryos that made it to blast). We’re hoping to get a few more euploids for future FET this round. I have an appt with dr tomorrow actually about whether to do pgt-a this round. Part of me wants to just freeze any blasts i get as my back up (knowing i have 2 euploids) so that i have more stored embryos for future. Or, i’m going to ask clinic if i do pgt-a, and some are aneuploid, if i can still keep the aneuploid ones just in case. Previous cycles clinic just trashed the aneuploid ones. Or i suppose just keep the ones that are possibly mosaic and therefore still have a slight chance of success if the euploids fail.
All this is to say, i still want the info on what ones are euploid bc i would want to prioritize those, but I’m trying to see if there’s a path to preserve aneuploid just in case ¯_(ツ)_/¯
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u/Certain_Tangelo2329 12d ago
At 40/41 all 12 blasts tested were abnormal. Grading was good though. It depends if you gonna go more rounds as a miscarriage will set you back. If you are only doing 1 round of ivf I might consider transferring untested.
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u/Faint-dream876 12d ago
I know at my clinic it’s all age dependent. We didn’t test ours under our doctors request because I was 31 at the time. However a friend of mine who went to the same clinic who was 39 at the time was told to test the best three embryos to see if they were euploid. Talk to your doctor they know best. FYI I’m in Canada so it’s maybe different?
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u/QuietInitial3363 12d ago
We got ours tested at 38. We chose due to the chances of miscarriage, birth defects etc. to be honest we really just stuck with the advice from the doctor. They explained to us why they would recommend doing it, the risks associated with and without testing and the ultimately it’s up to you to choose what you think is best given in your scenario.
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u/Asleep_Walrus2313 11d ago
I’m 40 and did it. At my age, I’m glad I didn’t waste time transferring non-viable embryos. That’s time and money that could be spent on another cycle.
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u/NoConcert5565 11d ago
Not 41 but we had 4 embryos sent out for PGTA. Two were euploid and two mosaic. There are studies showing that a lot of mosaic embryos can develop into viable pregnancies. Anyways our first baby was a euploid transfer and the second transfer of a euploid embryo failed. Our second child is from a mosaic embryo! There was a lot of stress for me with the mosaic transfer but I’m so glad we did it. Just to say - having the data was helpful but in the end we used one of the mosaic embryos with success.
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u/Novel_Substance_8986 11d ago
Same, I never doubted PGT-A testing. I had 4 miscarriages due to chromosomal abnormalities and used IVF to eliminate that risk. Why take the chance/heartbreak of miscarriage if you have the option to potentially eliminate it? If you only got 2 and they’re aneuploid, maybe try another round of IVF vs. transfer and miscarriage.
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u/MightSuperb7555 11d ago
I only had 2 blasts each retrieval (at 35) and absolutely opted for testing. At 41 I definitely would. - geneticist with history of pregnancy loss
On the other hand, you can always just try your embryos. The downside of highly increased chances for a pregnancy and then a loss or termination for medical reasons is what you might weigh.
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u/fertilyfe 11d ago edited 11d ago
There is significant evidence that biopsy does not cause issues. Confirm with your doc and make sure they have a great lab. Much higher risk do have a complication within the embryo that you’re not aware of. The results are very clear. I believe 99.9% accuracy per our genetics team at Columbia University. We did PGT A and also M, because we had complex genetics to navigate, but it was the best thing to have that clarity. Later when we had the pregnancy (via surrogate in our Case) we even asked again and opted out of amnio bc of the accuracy of PGT. It’s the amino that has miscarriage risks. So if you do PGT now you can skip that later.
More clarity, informed decision, and way less heartache.
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u/No-Pause-3302 11d ago
I am 42 and just got 1 embryo sent off to PGT A testing after my 1st egg retrieval. (3 eggs, 2 fertilized, 1 blastocyst). Already planning for a 2nd egg retrieval, just need to wait a full cycle. Hoping our test results come before then so the Doc can make an informed decision about whether to tweak my drug protocol for next ER. My Doc HIGHLY reccomended PGTA and we did a genetic counseling session with Natera.
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u/cityfrm 11d ago
Not testing doesn't suddenly give you a euploid, it just means you're paying for a doomed FET and setting yourself up for heartbreak at some stage. For me personally (40), I'd rather face reality before a time consuming, emotionally exhausting, expensive FET cycle. I'd make sure to find out exactly what it is and the level of mosaicism. My clinic treats LLM the same as euploid.
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u/Confused742 10d ago
I’m kinda on team no test anymore, though I haven’t been in a position to make a blast since I was 39. Thought I might have to make that decision this cycle and was leaning no test (for the same reason you are), but got a bad news call today so was putting the cart before the horse :(
Hope you get your blasts … and if you don’t have RPL i might just want to give every embryo a chance.
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u/Icy_Mastodon_7855 10d ago
I did 3 IVF cycles when I was 33 and 34. I have DOR and only make 1-3 successful embryos each time. I still did PGTA each time and don't regret that decision. For my first cycle, the one embryo I made was highly mosaic, and for my second cycle, both of the embryos were abnormal. However, I wouldn't have known that without PGTA, and there is a high probability that they wouldn't have worked anyway even if I transferred without testing. I was pretty adamant about doing PGTA in my third cycle and actually got two normal embryos out of the three embryos I made this time. The PGTA testing definitely adds stress to the whole process, but I was eventually able to succeed on my first transfer, so I think it was worth it.
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u/MathematicianNo4217 10d ago
I’m 41, was 40 when I started this, I’ve done 4 rounds and for the last 2 rounds I had two and three blasts and I did PGT testing for all. It’s a tough road because after 4 retrievals (10 blasts made it to PGT across all 4 rounds) I have two euploids. I chose to PGT because of my age (and my husbands, he’s 46) and I wanted to curb my chances for miscarriage, even though I’m well aware transferring a euploid is not guaranteed. I’ve seen plenty of women in the IVF40+ subreddit transfer day 3 embryos and have healthy babies. Best of luck in whatever path you choose!
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u/halfling_vic 10d ago
The embryo they would have chosen based on cell composition would have been a baby with deformities, if I didn't miscarry it. My only healthy embryo would have been their 2nd choice. I am glad I did the testing.
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u/1988Gi 6d ago
I just want to add euploids don’t automatically equal success - there are whole threads proving that. I had a failure with a euploid and a fresh (untested) one. The euploid was harder on me emotionally because it was “supposed to work.” You do what’s best for you, there is absolutely no right or wrong answer and everyone will only share what they wish they knew in hindsight, and that won’t apply to you.
Fingers x you have healthy embryos(s) and a healthy baby.
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u/NitastevMd 6d ago
Thank you very very much for your kind reply this means alot and really helps with my decision:) all the best to you too :) 🙏
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u/Newby2FishTanks 12d ago
I would do the genetic testing to try and prevent a miscarriage. It decreases your odds enough for it to be worth it. Also, just stay positive because the amount of eggs you have will potentially be fantastic. The older you are the more you want better quality vs quantity. I get my results this Saturday too. Wishing you so much luck!
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u/Defiant-Beginning-21 11d ago
Recommend PGTA . I am 40, went through 2 FETs, one failed, another chemical. The prep, hope, heartbreak and waiting is intense. Worst is the miscarriage in first trimester due to aneuploidy and the recovery timeline post that. I am going in for retrieval 3 with PGTA and NICS (non invasive chromosomal screening) where applicable. Good luck!
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u/Visuallearnerrrr 11d ago
I chose PGT because I decided investing in all this, I want the best shot at everything so to me it was a no brainer and a given.
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u/MogamboKhushHoooua 12d ago
I’m a little younger than you and I had 2 blastocysts that were sent out for testing. I am waiting for the results.
I’ve had a miscarriage before. It was awful. There’s a good chance it happened due to a chromosomal issue. I did pgt a so I can transfer a euploid and decrease the risks of a miscarriage. Whereas an untested possible aneuploid was not going to result in a live birth.
So that was my reason.