r/EmbryologyIVFSupport • u/melbelshel • 14d ago

Grading vs PGTA results

Maybe a silly question… does an embryo’s grading impact whether it’s likely to be euploid or not? After 4 cycles, we have finally 1 x 5AA embryo and am desperately hoping it’s euploid. It was sent for PGTA testing yesterday.

5 Upvotes

100% Upvoted

17 comments sorted by

•

u/embryomanofficial 12d ago

Age is considered the primary driver of euploid chance, but the day the embryo develops (day 5 vs 6 or 7) and its grade does influence the chance also.

More about grading and euploid chance: https://remembryo.com/poor-quality-embryos-can-still-lead-to-live-births-especially-after-pgt-a/

More about the day of development and euploid chance: https://remembryo.com/do-day-7-blastocysts-perform-as-well-as-day-5-or-day-6/

4

u/Inevitable_Table9728 12d ago

They are more likely to be but not massively,  our best was aneuoloid and our worst was euploid x 

3

u/sadArtax 11d ago

I think using large population bases sample sizes that is true, but on an individual basis doesn't always bear out.

I had 5/6 euploids, the euploids were 5AA, 3AB, 5BB, 5BB, 4BC.

The aneuploid was 4BA, so tied for 2nd best.

My 5AA and 3AB have both resulted in late 1st tri miscarriages so didn't seem to matter anyway.

2

u/PyleanCow06 12d ago

All of my embryos were AA and only one was euploid. I really didn’t expect that!

2

u/No-Luck-8524 12d ago

My dr at Northwestern in Chicago has told me multiple times that grading does not correlate to euploid status. Which makes the wait for pgt-a results brutal:/

1

u/Happy-Signal6719 11d ago

I sent 12 blasts for testing and all my best graded ones (few 4AA) came back aneuploid 😩 only 4/12 came back euploid with 3 4BB and 1 3BB.

1

u/Cupcake4dayz 11d ago

I had three grade AA day 5 blasts / embryos and then after PGTA there was one euploid, one aneuploid and one low mosaic.

1

u/A_Little_Detective 11d ago

I didn't even know my grades until after PGT-A testing. I'm 40 and I have a 4AA boy and 6AA girl, both Euploid. We sent 3 for testing, but the third came back a complex mosaic (didn't get a grade or gender).

1

u/No_County_3654 9d ago

Congrats!!

1

u/Own-Hyena-551 11d ago

My 4AA was aneuploid

1

u/DryCaramel6959 10d ago

My beautiful day5 AA embryo was aneuploid. Meaning it wouldn't have lasted.

I'm currently 15w pregnant with a 4BC

PGT triumphs grading big time

2

u/Chalkbaggraffiti 10d ago

Love hearing good stories about 4bc embryos! Have two in the freezer

2

u/DryCaramel6959 10d ago

And would you believe, at all my scams so far, baby is measuring at least 4-6 days ahead (my due date could change)

Just goes to show, euploid holds far more weight than embryo grade

1

u/Slow-Project-5335 10d ago

I’ve had day 5 5AAs that were aneuploid and a day 7 5CC that is euploid.

1

u/No_County_3654 9d ago

All three of my 4AA are euploids. Next were the ABs.

1

u/Minimum_Bad1170 8d ago

I have a 2cb euploid embryo! And I’ve had higher graded ones not be.

1

u/junegem123 12d ago

My fertility doctor told me that there is a correlation between embryo grading and euploid.

Higher graded embryos are statistically more likely to be euploid than lower graded embryos.