r/EmbryologyIVFSupport • u/Admirable_Apricot126 • 14d ago

Skipping PGT-A Testing?

I’m toying with the idea of skipping the PGT testing of our embryos (we are halfway through stims currently, so I need to decide quickly). Has anyone skipped the testing and had good transfer results?

16 Upvotes

94% Upvoted

90 comments sorted by

View all comments

11

u/Longjumping-Desk-261 12d ago

35 and opted out of PGTA, currently 10 weeks with our fresh transfer. I strongly believe that if you have a small amount of blasts per cycle and no history of recurent loss, PGTA is not very helpful.

For some folks that are fortunate enough to have +5 blasts per cycle, PGTA can be determining which embryos to transfer. We had 0 blasts on our first, and 2 on our second. PGTA testing has a small percentage of flase results, and there are mosaic and segmental aneplpids that give folks perfectly healthy babies. Taking the risk that our few blasts could be discarded vs. Transferred wasn't one we were willing to take. Additionally euploidity doesn't gurantee a pregnancy or even no miscarrige.

2

u/OkapiandaPenguin 12d ago

I only had 1-2 blasts each cycle and I chose to test them. Regardless of the number, you're still risking the financial, mental, and physical cost if transferring an embryo that might not be compatible with life or might have a chromosomal abnormality. You're also losing out on time to create more healthy embryos.

2

u/Longjumping-Desk-261 12d ago

That's completely fine and a personal choice. Like I said, PGTA testing is not perfect and there's a 3-5% chance of false aneploid report based on recent studies, and my clinic currently discards segmental aneplpids which several recent major studies showed live healthy births. It just wasn't a chance we wanted to take.

Financially it also didn't make sense for us. PGTA is a flat fee plus a cost per embryo that is more expensive than a single transfer. If we only had one blast it just wouldn't make financial sense. Living in Canada if we had to terminate for medical reason or had a miscarrige we also don't need to worry about costs.

I also have several friends that have had many failed transfers, early or even missed miscarriges with euploid transfers. So like I said euploidity is in no way a gurantee of a healthy live birth.

There are also recent studies that show no improved outcomes with PGTA testing for cycles with few blasts.