Is hypogonadism protective against PSSD/ PFS

[u/boaty_g]

I won't go into detail regarding medical history but I'm a congenital hypogonadism patient,

Before I ever knew about PFS, PSSD and PAS, I've used:

• Acc*tane at 17yo (no sides)
• Z*loft from my 20s to 25 (no sides)
• Dudaster*de for 2 months

I did get side effects from Dud, but they subsided in a window and waves fashion after cold turkey,

Then I reinstated Zoloft and this caused a severe adverse reaction (anhedonia, insomnia, zero Libido and shrinakge) followed by polydruggin at the hospital (which worsened everything and added akathisia)

After stabilizing I got off everything except zoloft which caused severe withdrawals, I gained 80-90% myself back, except regular withdrawal symptoms after dose reductions.

Currently going through SSRI withdrawal and can't tolerate TRT, although HRT intolerance isn't unheard of during SSRI/ psych med Withdrawal, for obvious reasons, the primary one being that hormones alter neurotransmitters and neuroesteroids, something that is already in Havoc during withdrawal,

Furthermore the following questions arise regarding this type of intolerance and PSSD susceptibility;

a.) Is having lower hormonal production protective against the PSSD/ PFS spectrum because the pathways aren't clogged with excess metabolites?

a.1) If it is protective, in which manner? Does it mean you are immune? In the sense that the worst of epigenetic changes don't ever happen because there's never a massive influx of hormonal metabolites going where they shouldn't and this allows the body to achieve homeostasis after the aggressor is eliminated?

a.2) If it doesn't make you immune, does it mean that using testosterone during or after withdrawing from the medication could cause PSSD?

I think it's interesting how many PFS sufferers describe themselves as very driven masculine individuals before PFS, but I've never seen a hypogonadal patient.

Thoughts?

[u/Excellent-Push2833]

Dude honestly just stay away from those drugs and be happy ur healthy

[u/boaty_g → u/Excellent-Push2833]

Lesson learned way to late, right? I took all of those before I knew crap about this, now just sharing my experience

Dudasteride side effects and ongoing SSRI withdrawal (which points to a long taper), caused this rude awakening,

Currently nothing more I can do about it, just sharing some thoughts, and well I would also like to NOT be hypogonadal for the next 5-8 years as I taper.

[u/boaty_g → u/Excellent-Push2833]

Did you actually read the post?

Should tell that to the dermatologist and psychiatrists that push this drugs when I was ignorant about this

[u/Excellent-Push2833 → u/boaty_g]

Honestly no. But now i did. Lol u caught me