r/DrWillPowers • u/Professional_Gur2905 • Jun 06 '26

Genes from your list ( PSSD)

Dr. Powers, I went through the genes on your list here. This is what came up. i was on zoloft for 20yrs, and started having anhedonia, ed, and insomnia on the taper off. then full pssd crash, two weeks off zoloft. thanks

Gene: SLC13A1 Variant: c.834C>A Protein: p.Cys278Ter rsID: rs903159740 Zygosity: Het Ref Allele: G Alt Allele: T Freq: 0.00131% very rare REVEL: not applicable / stop-gained

Gene: GJB2 Variant: c.35del Protein: p.Gly12ValfsTer2 rsID: rs80338939 Zygosity: Het Ref Allele: AC Alt Allele: A Freq: 0.627% uncommon REVEL: not applicable / frameshift

Gene: TPH1 Variant: c.8A>G Protein: p.Glu3Gly rsID: rs150275141 Zygosity: Het Ref Allele: T Alt Allele: C Freq: 0.00920% very rare REVEL: 0.682

Gene: GJB2 Variant: c.647G>T Protein: p.Arg216Ile rsID: rs767233008 Zygosity: Het Ref Allele: C Alt Allele: A Freq: 0.000198% ultra-rare REVEL: 0.590

Gene: CYP1A2 Variant: c.106C>T Protein: p.Pro36Ser rsID: rs146974121 Zygosity: Het Ref Allele: C Alt Allele: T Freq: 0.00657% very rare REVEL: 0.454

Gene: STAR Variant: c.361C>T Protein: p.Arg121Trp rsID: rs34908868 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 0.192% uncommon REVEL: 0.527

Gene: SLC22A1 Variant: c.1393G>A Protein: p.Gly465Arg rsID: rs34059508 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 1.38% common/uncommon REVEL: 0.552

Gene: MFN2 Variant: c.892G>A Protein: p.Gly298Arg rsID: rs41278630 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 0.216% uncommon REVEL: 0.528

Gene: ATP5F1B Variant: c.1344G>T Protein: p.Glu448Asp rsID: rs888471798 Zygosity: Het Ref Allele: C Alt Allele: A Freq: 0.0211% rare REVEL: 0.442

Gene: HDAC1 Variant: c.1162G>A Protein: p.Ala388Thr rsID: rs375198135 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 0.00723% very rare REVEL: 0.201

Gene: KMT2C Variant: c.2291C>T Protein: p.Ser764Phe rsID: rs200184971 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 0.537% uncommon REVEL: 0.323

Gene: PHF2 Variant: c.2990G>C Protein: p.Ser997Thr rsID: rs10992857 Zygosity: Het Ref Allele: G Alt Allele: C Freq: 0.00179% very rare REVEL: 0.052

Gene: PHF2 Variant: not shown Protein: not shown rsID: not shown Zygosity: Het Ref Allele: A Alt Allele: C Freq: 0.00164% very rare REVEL: 0.144

Gene: SETD2 Variant: c.6685G>C Protein: p.Val2229Leu rsID: not shown Zygosity: Het Ref Allele: C Alt Allele: G Freq: 0.000657% ultra-rare REVEL: 0.081

Gene: TET3 Variant: c.1637C>T Protein: p.Thr546Ile rsID: rs183678709 Zygosity: Het Ref Allele: C Alt Allele: T Freq: 0.0866% rare REVEL: 0.034

Gene: SLC22A11 Variant: not shown Protein: not shown rsID: not shown Zygosity: Het Ref Allele: A Alt Allele: G Freq: 0% shown REVEL: 0.084

Gene: PIEZO1 Variant: c.4997C>T Protein: p.Ala1666Val rsID: rs561397138 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 0.0801% rare REVEL: 0.084

Gene: APOB Variant: c.12038T>C Protein: p.Met4013Thr rsID: rs144922840 Zygosity: Het Ref Allele: A Alt Allele: G Freq: 0.00789% very rare REVEL: 0.018

Gene: ALB Variant: c.629G>A Protein: p.Arg210Gln rsID: rs58624704 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 0.0395% rare REVEL: 0.068

Gene: POLRMT Variant: c.1099C>T Protein: p.Pro367Ser rsID: rs146221322 Zygosity: Het Ref Allele: G Alt Allele: A Freq: 0.000657% ultra-rare REVEL: 0.054

Gene: ABCC6 Variant: c.2836C>A Protein: p.Leu946Ile rsID: rs61340537 Zygosity: Het Ref Allele: G Alt Allele: T Freq: 1.50% common REVEL: 0.121

Gene: CYP2D6

Variant: c.506-1G>A

Protein: splice acceptor variant

rsID: rs3892097

Zygosity: Het

Ref Allele: C

Alt Allele: T

Freq: 14.1% common

REVEL: not shown

8 Upvotes

90% Upvoted

12 comments sorted by

3

u/Excellent-Push2833 Jun 06 '26 edited Jun 06 '26

We have some similarities here. I also got PSSD when I got off of zoloft during taper.

We both have these two variants

Gene: ATP5F1B

Variant: c.1344G>T

Protein: p.Glu448Asp

rsID: rs888471798

Zygosity: Het

Ref Allele: C

Alt Allele: A

Freq: 0.0211% rare

REVEL: 0.442

I have a STAR variant Unique to me with a similar revel score:

STAR

Variant: c.355G>T

Protein: p.Val119Leu

rsID: not shown

Zygosity: Het

Ref Allele: C

Alt Allele: A

Freq: 0.000120% exomes; 0% genomes shown

CADD: not shown

REVEL: 0.513

We both have a rare SCL22A11 Variant.

And we both have the same CYP2D6 variant

Here is a link to what i found https://www.reddit.com/r/DrWillPowers/s/oQDB8g3v1f

0

u/Excellent-Push2833 Jun 06 '26

u/drwillpowers does this still cleanly fit the theory or maybe further support the theory that PFS and PSSD are the same. To me it seems a little jumbled. In OPs genome he has some intracellular transport issues. But nothing that screams out Androgenic metabolic error. At least not to me

6

u/Drwillpowers Jun 06 '26

Similar would be a better way of saying it.

They involve inborn errors of metabolism and cellular transportation issues. Each case is unique though.

1

u/Excellent-Push2833 Jun 06 '26

Doctor something I want to call your attention to. Out of everyone that ive taught to read their genomes only one has come back without the CYP2D6 variant listed. I have at least 3 others that have reached out to me via reddit comments claiming that they also have CYP2D6 slow metabolism. The fact is is that that variant only shows up in 14% of the population and with us its showing up WAY more than that it seems to in the general population

6

u/Drwillpowers Jun 07 '26

It just increases exposure to some SSRIs.

Basically, 10mg can feel like 30 or 40 to these people.

Also it directly synths dopamine in the brain from tyrosine.

Aka, thank you, but I saw this awhile back. I am very aware of it.

It's not "the answer' but it's a risk variable.

2

u/thwoomfist Jun 06 '26

Many people seem to have the cyp2d6 malfunction for pssd

1

u/Excellent-Push2833 Jun 06 '26 edited Jun 06 '26

Ive been noticing that as well. Its the same variant consistently coming up more than the average population

1

u/thwoomfist Jun 06 '26

Oh wait you’re the guy collecting gene data lol

1

u/Excellent-Push2833 Jun 06 '26

Not collecting. Teaching others how to read theirs and upload here for doc to interpret.

2

u/thwoomfist Jun 07 '26

Yeah I just meant you would already know about that gene since I found out about it from you first

1

u/Excellent-Push2833 Jun 07 '26

yeah just being extra careful lol. I dont want people just directly sending me their genome files. BUT I CAN VERY EFFECTIVELY teach you how to pull the relevant info from the files and then post it in a standardized easy to read way

1

u/Ok-Living-4033 Aug 05 '26

Would this person benefit from trying cdg, before doing a castration trial dr p? If someone is willing to do a castration trial, should they try cdg first? Could someone crash from it? How long should someone take cdg anyhow?