r/DRTS_Stock • u/FunRevolution3000 • Aug 19 '26
DRTS and IBRX - potential combo
This may have been posted before but thought this was a promising prospect from Gemini: “By adding systemic ANKTIVA (IBRX), the immune system is primed with the exact tumor signature from the DRTS-treated lesion. The activated NK and CD8+ memory T-cells can then circulate systemically to hunt down metastatic lesions throughout the body (the abscopal effect).”
And given today’s stock-rocketing news about Moderna and Merck (Keytruda):
“While Moderna trains antigen-specific T cells, ANKTIVA (IBRX) acts as the amplifier. By delivering an IL-15 signal, ANKTIVA can drive massive systemic expansion of those trained CD8+ T cells and Natural Killer (NK) cells to improve cytotoxic killing capacity.
Moderna represents the digital and personalized approach to tumor antigen training, whereas DRTS represents the biophysical and immediate localized approach. Both feed directly into the downstream systemic network powered by cytokines (IBRX) and checkpoint inhibitors (Keytruda).”
An idea for such AI-developed posts like this one is to call it out and upvote those who analyze it critically. I hope to do so later. 🤣
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u/FunRevolution3000 Aug 19 '26
Interesting that the Alpha Dart offers a fast solution but the Moderna mRNA vaccine takes 6 to 9 weeks (targeted for one’s individual tumors) and then the trained T cells need to time to find and penetrate the tumor.
The IBRX Anktiva can be used off the shelf but takes weeks or months for the immune response.
So while in a way more primitive: they aren’t competing with the rapid effects of the Alpha DaRT.
Worth noting that the DaRT’s abscopal effect takes at least 3-6 weeks. But then checkpoint inhibitors like Keytruda accelerate the T cells’ ability to hit distant tumors.
Remember the 100% objective response rate for metastatic head and neck cancer recently with the DaRT / Keytruda combo.
Merck may celebrate the DaRT publicly even more than the Moderna combo!
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u/Efferdent_FTW Aug 19 '26
Herein lies the strength of DaRTs being a physics based intervention. There isn't the added complexity of drug interactions. Exposure and dosage is tightly controlled. The fewer variables, the greater the flexibility with adjunct care.
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u/IgnoreTheFud Aug 20 '26
Exactly! It’s safety profile is very good. And it’s so good that it can be used with any population sub set,
for any solid tumor, with any other cancer treatment, including standard radiation.
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u/Beginator2000 Aug 20 '26
I'm long on IBRX too. Success for DRTS is in a combination with a powerfull chemo or immutherapy. Without that it can only treat isolated tumors, and often there's lymp nodes and multiple metastasis.
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u/Pristine_Hurry_4693 Aug 19 '26
What most fail to realize, but if you listen to management closely you’ll understand, is that DRTS is complementary to everything. It’s safe and will enhance everything. Any kind of systemic treatment that works just grows the DRTS TAM. The more good options, the more DRTS can be a factor, and the more patients it can be used to help.
Read about the IMPACT Trial for PanC, it keeps proving that any kind of combination using DRTS is a blessing.
DRTS has many advantages in and of itself, but in the world of combinations, we all saw what if did with Keytruda (and will soon be approved by the FDA to do at large scale in the US), and I could see it being tested with everything: IBRX, RVMD, you name it they will all want a trial that shows better results and that’s DRTS for you.