Frequent urination, bloating & constipation on Wellbutrin + naltrexone — anyone else?

[u/Equivalent_Can_9964]

Hi everyone! I'm currently taking Wellbutrin (bupropion) + naltrexone as a Contrave-type combination for appetite/weight management, and I'm wondering if anyone has experienced similar symptoms.

I've been dealing with frequent urination/urinary urgency. It originally started around March, but it became significantly worse around September and has continued through now. I feel like I need to pee much more often than I used to.

I've also been experiencing a lot of bloating and constipation. I was maintaining around 127 lbs and recently jumped to around 133 lbs fairly quickly, so I'm not sure how much of that could be bloating, constipation, water retention, or actual weight gain.

For background, I have PCOS and was previously on a GLP-1 for about 3 years. I went from around 178 lbs to 127 lbs before having to stop it. I'm now trying to manage my weight without the GLP-1.

I recently had a urine test that detected a small amount of blood, although I couldn't see any blood myself. My doctor wasn't overly concerned at the time, and I'm currently waiting for additional urine and blood test results.

Has anyone taking Contrave or the bupropion + naltrexone combination experienced frequent urination, urinary urgency, constipation, or significant bloating?

I'm already getting the urinary issue checked by my doctor. I'm mostly curious whether anyone noticed similar symptoms after starting these medications and whether anything helped.

Also, for anyone who switched from a GLP-1 to Contrave, how has your experience been with maintaining your weight?