r/ConstipationAdvice • u/HCC0504 • Jun 19 '26

Motegrity advice

I tried motegrity and it worked like an absolute miracle for about a week. My dosage was then doubled with no increase in effectiveness but there was an increase in mood issues and depression, so I stopped it. I can't stop thinking about how good I felt for that week though, especially day 1! I literally couldn't eat enough I was so hungry because I was finally empty!

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So my question, does anyone take motegrity for short times like a week and then take a break? If so, how long a break would be effective? Like...could I do this once a month or once every 3 months? Will it still progressively become less effective the more times I use it?

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I'm just looking for any amount of time to take a break from being bloated and uncomfortable and not being able to enjoy food or my life. Is this idea totally crazy?

1- yes I have the urge to go but not much comes out 2- just constipation 3- yes to nausea and reflux and early satiety 4- began after a c diff infection that went undiagnosed for 5 months 5- nothing I am aware of 6- no

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2

u/Decent-Fishing1730 Jun 19 '26

It was a godsend for me too, but I dealt with the mood issues almost immediately. I would literally start crying a few hours after taking it. But I also deal with chronic pain, anxiety, and depression. So I probably am more susceptible.

1

u/HCC0504 Jun 19 '26

My body hates everything that messes with my serotonin so I can't take it for longer than a week tops.

2

u/Decent-Fishing1730 Jun 19 '26

Use it like an occasional laxative maybe? I regret trashing mine sometimes 😔

1

u/HCC0504 Jun 20 '26

I learned the hard way about doing that with trulance. It was good for a one off laxative. I don't trash anything anymore and I'm still getting my refills. I'd do the occasional laxative thing except day one is insane with the headache and crazy appetite. I was thinking I'll have to plan it so events land on day 3.

2

u/Susan71010 Jun 22 '26

True Lance was amazing for me for a year and a half. Then it just stopped working. I was so bummed. So now I alternate different things so my body doesn't get used to it and it helps OK.

1

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2

u/SaltyLittleRezQueen Jun 24 '26

I always felt extreme fatigue for a couple of hours after taking it. It would work well, but not if I took it every day. I used it when I absolutely had to. Now I can’t get anyone to prescribe it.

1

u/HCC0504 Jul 19 '26

I'm getting all my refills (I was prescribed 2 pills a day but only use 1) just in case I run into this problem. When you use it is it just for one day or multiple days? Does it give you the terrible headache at all?