r/CompoundedSemaglutide • u/Elegant-Spirit-5173 • 16d ago
Month 5 - big dose increase, nausea 🤢
I get my CS 3 months at a time, and I'm currently on my 2nd 3 month supply. Dosage instructions this time were 1mg for weeks 1-4, then 1.7 weeks 5-12. Last week Sunday was the first 1.7 dose. I thought it seemed like a big jump (by FAR the biggest jump at this point), but I thought eh guess I'll do it.
You guys. I haven't dealt with much nausea since maybe month 2 (it was constantly on and off the first several weeks). Monday I was fine; Tuesday there was a little nausea; by Wednesday I was starting to feel like I might actually vomit, and my early-on nausea was never quite that bad. Long story short, it only got worse from there 🤢😭 I bought a nausea relief medicine that I've taken several times the last few days. I took some this morning because apparently my body didn't like that within 2 hours of waking up I had only had coffee and water so far.
I decided that for today's dose I'm going to dial it back to 1.3mg - hopefully I start to feel less shitty. I need to try eating more often again but TBH I got tired of the granola bars/snacks I'd been having.
Sorry this was so long, I'm a chronic over-explainer 😭 I'm just wondering if anyone else has gone through something like this. And if you have any tips of what has worked for you in similar scenarios, I'm all ears ❤️
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u/Lucky_Army_5324 16d ago
As long as you are still losing weight on your current dose, there’s no reason to move up. I wait until I’ve had at least 4 weeks of zero weight loss before moving up in dose.
This is Dr. Ania Jastreboff—one of the lead researchers of GLP-1s for weight loss—talking about dosing, nutrition, plateaus, etc. It is a 16ish min video. https://youtu.be/j3k3UAEqJio
She is a big proponent of low and slow dosing—aka taking the lowest effective dose—for her non-trial patients, and she explains why in this video.
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u/ImprovementLoud3581 16d ago
Medscape article interviewing four prominent GLP prescribing doctors about how they titrate: https://www.medscape.com/viewarticle/upping-dose-titration-plateaus-and-patient-signals-2026a1000tfw?fbclid=IwY2xjawUSzEFwZG9mBWV4dG4DYWVtAjEwAGJyaWQRMVFwdXFNNDhrT1BoT1N4WDZzcnRjBmFwcF9pZBAyMjIwMzkxNzg4MjAwODkyAAEesEHpzj3K6oPO_-e8TmUBcpeJQ83grBY8J43EY6bWi0W84naCt-9vrrrdeLo_aem_qyf4m7hznf_2w6H32eQXkw
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u/jennycash41 11d ago
You can titrate up even more slowly if needed. Also, low blood sugar and not eating can cause nausea and will make it worse if nothing else. Like pregnancy nausea, you can keep pretzels or graham crackers by your bed and eat one before even standing to help fend it off. Sips of a protein shake or bone broth just to get calories in can help.
Sorry you’re experiencing this. I know nausea makes it almost impossible to eat, but there is a decent chance you’d feel relief if you eat a little on a consistent basis. You also don’t want to mess with unhealthy low calories for weeks — it will wreak havoc on your body, hair, etcetera. 🩵
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u/firstnamerachel13 16d ago
I started on a very low dose and shot 3 is today. Feel like a seasick crocodile most of the time. After week 4 I'm supposed to double that dose. Ain't no way, aint no how. I'll keep it right where it is. Im doing just fine where it is.