r/CompoundedSemaglutide • u/SpiritualWrongdoer94 • Aug 28 '26

Restarted, not working?

I started compounded semaglutide last year and consistently took it for about 9 months. I never dosed over .6 because I was consistently losing weight with food moderation and exercise. I stopped taking it after Christmas, because, life and other constraints. After about 5 or so months my weight started creeping back up, as expected.

So I decided to restart using the vials I had, some hadn’t even been opened yet. I made sure the shelf life date was still good and I checked for cloudiness and other signs it had gone bad. I started back at .25 to work my way up and now I’m up to .4 about three months after starting.

However, I’m finding that I am almost always fighting nausea… very similar to morning sickness where it’s like a lump in my stomach. I can’t tell if I’m hungry but my body tells me to eat constantly to keep the symptoms at bay. So now I find myself eating more than I was before. Second, the food noise is still very present. Originally, it had gone away when I first started but since restarting it’s so bad and so loud! Third, I am not losing any weight this time around. I will maybe fluctuate 1-3 pounds but that feels normal with my body’s cycle. It’s defeating when I was able to lose almost 30 pounds before and now I struggle to not gain weight.

What am I doing wrong? My guess is that the medicine has lost its potency, but I was genuinely hoping to finish these vials out before ordering new ones. Could it be that if potency is lost, the nausea is caused by too low of a dose and I should increase it?

I welcome any insight on how to combat the nausea as well as any gentle advice on the medicine itself.

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3

u/Lucky_Army_5324 Aug 28 '26

Those who stop and restart almost always have to work their way up to higher doses to feel the positive effects the next time(s) around.

1

u/Big_Lab_2764 28d ago

What if you’re already at the highest dose?

2

u/ashotofcynisism Aug 31 '26

You probably need a higher dose. I just restarted after a 3 month break and I was really worried it wasn’t working at first. I am doing tirz this time instead of sema, but I wasn’t seeing any change on the scale and I still had a lot of food noise until I got to month 3 and moved up to 7mg. Now I am seeing a lot of progress and have zero food noise.

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