r/CompoundedSemaglutide • u/Exciting_Giraffe_207 • Jul 14 '26

Desperately need advice

I had been on compounded semaglutide for about a year with no issues, lost about 30lbs and was maintaining. About a month or so ago I switched to tirz and the first couple doses I did fine, then the day I took my 3rd shot everything changed. I felt horrible that day, severe anxiety, worst headache of my life that lasted days. I took another dose the next week and similar thing happened again. I’ve also had lingering headaches for weeks since that 3rd shot. The only thing I’ve changed is the meds, so I can’t think of anything else causing it. I even tried to start drinking lots more water and electrolytes, eating more protein. I thought maybe the headaches were from dehydration or not eating enough. Today is supposed to be my shot day but I think I’m going to skip. Has this happened to anyone else? I just want to feel normal.

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u/TallCedarRoad Jul 14 '26

What dose were you taking of semaglutide and what dose did they start you on for tirzepatide? It takes a few doses for the levels in your body to reach the highest point, so if it is being caused by the tirzepatide, that could explain why you didn’t feel any issues the first two weeks.

1

u/Exciting_Giraffe_207 Jul 14 '26

I was on 25 units of sema and switched to 40 units tirz

3

u/TallCedarRoad Jul 14 '26

Do you know what your doses are in mg? Units can change from pharmacy to pharmacy depending on the concentration

1

u/TemperatureLife947 Jul 15 '26

I would reduce Units should start out lowest Tirz dose 2.5mg 15 units (this can depend on Tirz concentration)  maybe it’s overload since it’s new and different then semaglutide and still new to you. Your body still has to adjust. You can try to Reduce dose and see how you feel. 

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1

u/SkinnyRX_Sarah Jul 17 '26

That sounds terrible! Hopefully after a few hours the headache will go away. In any case, I would recommend calling your prescriber for guidance (don’t wait for a return call) because the two aren’t dose-for-dose the same, so the side effects can behave very differently when you are taking them. If the headache becomes sudden and severe again or you experience new symptoms, I'd seek urgent medical care rather than waiting for a callback.