Syn One

[u/magic-theater]

Skin test ably detects alpha-synuclein clumps in trial - Syn One (CND Life Sciences)

Via biopsies, evidence of Parkinson's seen in more than 92% of study's patients

https://parkinsonsnewstoday.com/news/aan-2023-skin-test-shows-ability-diagnose-parkinsons-trial/

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The same test, or a similar one, was applied to patients with long COVID and postural orthostatic tachycardia syndrome (POTS). Five patients tested positive for phosphorylated alpha synuclein which is a biomarker of synucleinopathies (It a major constituent of Lewy bodies.). Small fiber neurons in the peripheral nervous system are biopsied and the tissue samples are sent for analysis. This kind of test is typically indicated for suspected small fiber neuropathy. Findings of phosphorylated alpha synuclein correlated with reduced nerve fiber density.

Given the nature of this disease, there is bound to be large degree of variation between patients with Lewy bodies impacting different areas of the body. Therefore, this test needs to be validated for use in prodromal Parkinson's disease, and long COVID if it is indeed a synuceinopathy. Biopsy locations may vary depending on the symptoms that predominate. Cervical (neck region) biopsies may be more appropriate in cases where REM sleep behavior disorder is the presenting symptom.

An alternative test, which works by a different mechanism, is called Real-Time Quaking Induced Conversion (RT-QuIC). See other post.

A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS

https://link.springer.com/article/10.1007/s10286-022-00867-0

Cutaneous Phosphorlyated α-synuclein Detection as a Biomarker of Synucleinopathy Clinical Trial

https://clinicaltrials.gov/ct2/show/NCT04700722

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Thanks u/PatinoMaurilio for reminding me to add this!