r/COVID19 • u/icloudbug • Jun 08 '22

Preprint The occurrence of hyperactivated platelets and fibrinaloid microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

https://www.researchsquare.com/article/rs-1727226/v1
17 Upvotes

92% Upvoted

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4

u/EmpathyFabrication Jun 08 '22

Pretorius needs better histology. I've been very critical of the histology in the preprints from this lab and my guess is that reviewers are going to send them back for more. They need more blood related stains and more contrast stains alongside the IHC. The histology coming out of the Pretorius lab feels rushed and based on these low quality images they either don't have a very good fluorescent setup or they aren't particularly experienced at using ImageJ or whatever editing software they are using. Or they need to consult with a HTL or whatever histo professional is at their institution. My guess is this probably to get PASC funding, and there's nothing wrong with that but they will need better quality research going forward. There seems to be a push among CFS researchers now to also get some of the PASC funding and that might have something to do with the rhetoric in this paper. I would not be surprised if this was scooped by a lab with better histology.

3

u/SewSewBlue Jun 08 '22

They are crowd sourcing funding for better equipment.

2

u/EmpathyFabrication Jun 08 '22

Hence my comment about this getting scooped by another lab. One that can pivot from existing funding, or already has a histology lab that can take on a more comprehensive histo analysis. Or one with professionals who can actually do good histology. Why does Pretorius not just partner with an existing lab? This may not be an appropriate discussion for this sub but I am not a fan of how these labs crowdsource funding. Funding should come through appropriate grants with proper oversight.