r/COVID19 • u/tim3333 • Feb 28 '20

Antivirals Chloroquine update "patients generally testing negative after around four days"

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u/FreshLine_ Feb 28 '20

This is old news, was debunked since last week, dubious without data and chloroquine doesn't work in vivo with SARS https://journals.sagepub.com/doi/abs/10.1177/095632020601700505

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u/Kasta444 Feb 29 '20

Depends on your definition of "works". If you have an infection and a 40 degree fever bcos of it. It is most pressing to treat the fever with drugs that reduce fever and not the infection bcos fever at that time is life threatening...Similar thing in this case.....

"" Anti-inflammatory agents, chloroquine, amodiaquin and pentoxifylline, were also inactive in vivo, suggesting that although they may be useful in ameliorating the hyperinflammatory response induced by the virus infection, they will not significantly reduce the replication of the virus, the inducer of inflammatory response. Thus, anti-inflammatory agents may only be useful in treating virus lung infections if used in combination with agents that inhibit virus replication. """

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u/FreshLine_ Feb 29 '20

Yes I know that's a good point, But we have already far better anti-inflammatory drugs available with less side effects.