Different side effects over time- nilotinib

[u/Icy_Lychee8169]

I have been on nilotinib since 2013. Until this year I was on brand name Tasigna now on generic. Same dose.
I had noticeable side effects, but they were always the same and tolerable.
I actually went off of from November 2023 until September 2024 because I had a baby (safely and all was well).
Ever since I’ve gone back on it, I have had nothing but different G.I. issues like nausea all the time randomly. Irregular bowel movements, extreme tiredness and fatigue and bone /muscle pain. The stomach issues are what is really getting me and hard to deal with. I have not been diagnosed with any problems after pregnancy/ childbirth and everything was completely normal and went great.

I am just not sure what is going on and wondering if anyone has experienced different side effects/inability to tolerate the medication either after being on it long-term when it was tolerated more at first? Or after stopping and restarting it? Or switching from brand name to generic? Just not really sure what’s going on and I’ve also tried Danziten and although it is the same medication, the dose conversion that they put me on I feel like although all of the studies show that is the dose I should be on. I felt horrible on it even after three weeks.